Sakamoto Shota, Kakehi Saori, Abudurezake Abulaiti, Kaga Hideyoshi, Someya Yuki, Tabata Hiroki, Yoshizawa Yasuyo, Naito Hitoshi, Tajima Tsubasa, Ito Naoaki, Kawamori Ryuzo, Watada Hirotaka, Tamura Yoshifumi
Department of Sports Medicine and Sportology, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.
Sportology Center, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Ther Adv Endocrinol Metab. 2024 Sep 27;15:20420188241280540. doi: 10.1177/20420188241280540. eCollection 2024.
Metabolic syndrome involves health problems influenced by aging and genetics. The glucokinase regulatory protein () rs1260326 polymorphism (Leu446) is associated with metabolic traits. This study explores the impact of the GCKR rs1260326 polymorphism on metabolic traits in older Japanese with focusing on sex-specific differences.
This cross-sectional study from the Bunkyo Health Study in Tokyo, Japan, examined 883 participants aged 65-84 years. Participants were excluded with diabetes, or on drug treatment for diabetes or dyslipidemia. The P446L polymorphism was analyzed and compared their characteristics of physical activity, dietary intake, body composition, and metabolic parameters.
Study participants with rs1260326 genotypes (C/C 20.7%, C/T 47.6%, T/T 31.7%) had a median age of 72 years, and 60.4% were women. Men with the T/T genotype, as compared to the C/C genotype, had a lower body weight, body mass index (BMI), and skeletal mass index. This genotype also associated with lower fasting insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), and higher Matsuda index, but not after adjustment for age, BMI, and physical activity. In contrast, women with the T/T genotype, compared to the C/C genotype, showed higher C-reactive protein, fibroblast growth factor 21, and Matsuda index. They also had lower fasting insulin, insulin area under the curve, and HOMA-IR; with these associations being independent of age, BMI, and physical activity.
The rs1260326 genotype-affected metabolic traits differentially by sex in older Japanese. This highlights the need to consider sex differences in -related metabolic outcomes.
代谢综合征涉及受衰老和遗传影响的健康问题。葡萄糖激酶调节蛋白（GCKR）rs1260326多态性（Leu446）与代谢特征相关。本研究探讨GCKR rs1260326多态性对日本老年人代谢特征的影响，并重点关注性别差异。
这项来自日本东京文京区健康研究的横断面研究，对883名年龄在65 - 84岁的参与者进行了检查。排除患有糖尿病或正在接受糖尿病或血脂异常药物治疗的参与者。分析P446L多态性，并比较他们的身体活动、饮食摄入、身体成分和代谢参数特征。
具有rs1260326基因型（C/C 20.7%，C/T 47.6%，T/T 31.7%）的研究参与者中位年龄为72岁，60.4%为女性。与C/C基因型相比，T/T基因型的男性体重、体重指数（BMI）和骨骼质量指数较低。该基因型还与较低的空腹胰岛素、胰岛素抵抗稳态模型评估指数（HOMA-IR）以及较高的松田指数相关，但在调整年龄、BMI和身体活动后则无此关联。相比之下，与C/C基因型相比，T/T基因型的女性C反应蛋白、成纤维细胞生长因子21和松田指数较高。她们的空腹胰岛素、胰岛素曲线下面积和HOMA-IR也较低；这些关联独立于年龄、BMI和身体活动。
在日本老年人中，GCKR rs1260326基因型对代谢特征的影响存在性别差异。这凸显了在与GCKR相关的代谢结果中考虑性别差异的必要性。
