Dao Hiep Huu Hoang, Burns Mason Jenner, Kha Richard, Chow Clara K, Nguyen Tu Ngoc
Westmead Applied Research Centre, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2145, Australia.
Department of Cardiology, Westmead Hospital, Westmead, NSW 2145, Australia.
Geriatrics (Basel). 2022 Jul 26;7(4):76. doi: 10.3390/geriatrics7040076.
Both metabolic syndrome (MetS) and frailty are associated with increased all-cause mortality, yet the complex interplay between these two conditions has not adequately been elucidated. We aim to analyse the relationship between MetS and frailty through a systematic review of the literature with meta-analyses.
A literature search was conducted via MEDLINE and EMBASE. Studies were included if validated frameworks for defining frailty and MetS (presence of at least 3 out of the five constitutive components: abdominal obesity, high fasting blood glucose, hypertension, hypertriglyceridaemia, and low high-density lipoprotein level) were utilised, in addition to the inclusion of participants aged 60 or older.
Eleven studies were included, all observational. All were in community-dwelling older people, 9 cross-sectional and 2 longitudinal. Most of the studies used Fried's frailty phenotype. The prevalence of frailty ranged from 0.9% to 14.8% in population-based studies and 35.6% in the outpatient clinic setting. The prevalence of MetS was also higher in the outpatient clinic setting at 47.5%, compared to 17.5-41.0% in the community-dwelling populations. The meta-analysis of 11 studies showed that MetS was associated with an increased risk of frailty (pooled OR 1.73, 95% CI, 1.41-2.13).
This systematic review and meta-analysis suggest that frailty was more prevalent in older people with MetS compared to older people without MetS. The study findings suggest the importance of frailty screening in older people with MetS and a distinct role of managing MetS in preventing frailty in older people.
代谢综合征（MetS）和衰弱均与全因死亡率增加相关，但这两种情况之间的复杂相互作用尚未得到充分阐明。我们旨在通过对文献进行系统综述并进行荟萃分析来分析MetS与衰弱之间的关系。
通过MEDLINE和EMBASE进行文献检索。如果使用了用于定义衰弱和MetS的经过验证的框架（五个构成成分中至少存在3个：腹型肥胖、空腹血糖高、高血压、高甘油三酯血症和低高密度脂蛋白水平），并且纳入了60岁及以上的参与者，则纳入研究。
纳入了11项研究，均为观察性研究。所有研究均针对社区居住的老年人，9项为横断面研究，2项为纵向研究。大多数研究使用弗里德衰弱表型。在基于人群的研究中，衰弱的患病率在0.9%至14.8%之间，在门诊环境中为35.6%。门诊环境中MetS的患病率也更高，为47.5%，而社区居住人群中为17.5%-41.0%。对11项研究的荟萃分析表明，MetS与衰弱风险增加相关（合并比值比1.73，95%置信区间，1.41-2.13）。
这项系统综述和荟萃分析表明，与没有MetS的老年人相比，患有MetS的老年人中衰弱更为普遍。研究结果表明，对患有MetS的老年人进行衰弱筛查很重要，并且管理MetS在预防老年人衰弱方面具有独特作用。
