Bošnjak Ivica, Bedeković Dražen, Selthofer-Relatić Kristina, Roguljić Hrvoje, Mihaljević Ivica, Dukić Darko, Bilić-Ćurčić Ines
Department of Cardiovascular Diseases, Internal Medicine Clinic, University Hospital Centre Osijek, Osijek, Croatia.
Department of Pathophysiology, Faculty of Medicine, J. J. Strossmayer University of Osijek, Osijek, Croatia.
Front Cardiovasc Med. 2024 Sep 11;11:1458120. doi: 10.3389/fcvm.2024.1458120. eCollection 2024.
The aim of this study was to investigate serum levels of galectin-3 (Gal-3) and N-terminal pro-brain Natriuretic Peptide (NT-proBNP) in patients with stable obstructive coronary artery disease, as well as their potential to predict clinical outcomes.
This was a single-center cross-sectional cohort study. 168 patients were divided into three groups: percutaneous coronary intervention (PCI) group (N 64), coronary artery bypass graft surgery (CABG) group (N 57), and group with no coronary stenosis (N 47). Gal-3 and NT-proBNP levels were measured and the Syntax score (Ss) was calculated.
The mean value of Gal-3 was 19.98 ng/ml and 9.51 ng/ml ( < 0.001) in the study group and control group, respectively. Highest value of Gal-3 was found in the group of subjects with three-vessel disease ( < 0.001). The mean value of NT-proBNP in the study group was 401.3 pg/ml, and in the control group 100.3 pg/ml ( = 0.159). The highest value of NT-proBNP was found in the group of subjects with three-vessel disease ( = 0.021). There was a statistically significant association between Gal-3, NT-proBNP and occurrence of adverse cardiovascular event ( = 0.0018; = 0.0019).
Gal-3 and NT-proBNP could be used as an additional tool for diagnosis and severity assessment of stable obstructive coronary artery disease. Furthermore, it could help identify high-risk patients who could experience major adverse cardiovascular events.
本研究旨在调查稳定型阻塞性冠状动脉疾病患者血清半乳糖凝集素-3（Gal-3）和N末端脑钠肽前体（NT-proBNP）水平，以及它们预测临床结局的潜力。
这是一项单中心横断面队列研究。168例患者分为三组：经皮冠状动脉介入治疗（PCI）组（n = 64）、冠状动脉旁路移植术（CABG）组（n = 57）和无冠状动脉狭窄组（n = 47）。测量Gal-3和NT-proBNP水平并计算Syntax评分（Ss）。
研究组和对照组Gal-3的平均值分别为19.98 ng/ml和9.51 ng/ml（P < 0.001）。三支血管病变组Gal-3值最高（P < 0.001）。研究组NT-proBNP的平均值为401.3 pg/ml，对照组为100.3 pg/ml（P = 0.159）。三支血管病变组NT-proBNP值最高（P = 0.021）。Gal-3、NT-proBNP与不良心血管事件的发生之间存在统计学显著关联（P = 0.0018；P = 0.0019）。
Gal-3和NT-proBNP可作为稳定型阻塞性冠状动脉疾病诊断和严重程度评估的辅助工具。此外，它有助于识别可能发生主要不良心血管事件的高危患者。
