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半乳糖凝集素-3 在心房颤动中的作用：机制与治疗意义。

Galectin-3 in Atrial Fibrillation: Mechanisms and Therapeutic Implications.

机构信息

Cardiology Department, Trousseau Hospital, François Rabelais University, 37000 Tours, France.

Biochemistry Department, Trousseau Hospital, François Rabelais University, 37000 Tours, France.

出版信息

Int J Mol Sci. 2018 Mar 25;19(4):976. doi: 10.3390/ijms19040976.

DOI:10.3390/ijms19040976
PMID:29587379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5979515/
Abstract

Maintenance of atrial fibrillation is a complex mechanism, including extensive electrical and structural remodeling of the atria which involves progressive fibrogenesis. Galectin-3 is a biomarker of fibrosis, and, thus, may be involved in atrial remodeling in atrial fibrillation patients. We review the role of galectin-3 in AF mechanisms and its potential therapeutic implications.

摘要

心房颤动的维持是一个复杂的机制，包括心房的广泛电重构和结构重构，涉及进行性纤维化。半乳糖凝集素-3 是纤维化的生物标志物，因此可能与心房颤动患者的心房重构有关。我们回顾了半乳糖凝集素-3 在 AF 机制中的作用及其潜在的治疗意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b53/5979515/ba9fa5d1df67/ijms-19-00976-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b53/5979515/ae23449aa810/ijms-19-00976-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b53/5979515/649300f9d3ed/ijms-19-00976-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b53/5979515/ba9fa5d1df67/ijms-19-00976-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b53/5979515/ae23449aa810/ijms-19-00976-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b53/5979515/649300f9d3ed/ijms-19-00976-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b53/5979515/ba9fa5d1df67/ijms-19-00976-g003.jpg

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Serum Galectin-3 level, not Galectin-1, is associated with the clinical feature and outcome in patients with acute ischemic stroke.
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Basic Res Cardiol. 2024 Apr;119(2):215-242. doi: 10.1007/s00395-024-01038-0. Epub 2024 Mar 12.
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