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使用植物化学功能化金纳米颗粒的纳米阿育吠陀医学治疗乳腺癌的方法

Nano-Ayurvedic Medicine Approaches Using -Phytochemicals Functionalized Gold Nanoparticles Against Breast Cancer.

作者信息

Thipe Velaphi C, Hall Nya, Pandurangi Amoolya, Ajayi Samuel, Emeh Prosper, Gauttam Iti, Ghamgui Rania, Hameedat Fatima, Khelil Sihem, Ly Nhu Ky, Salim Mahmoud, Waleed Anum Shahid, Hegde Prajna, Hegde Vrushali, Prakash Deepa, Hegde Ilaadevi, Katti Kavita, Raphael Karikachery Alice, Roger Emilie, Landreau Anne, Katti Kattesh V

机构信息

Department of Radiology, University of Missouri, Columbia, MO, 65212, USA.

Department of Biology, Saint Louis University, St. Louis, MO, 63103, USA.

出版信息

Nanotechnol Sci Appl. 2024 Sep 23;17:189-210. doi: 10.2147/NSA.S478533. eCollection 2024.

DOI:10.2147/NSA.S478533
PMID:39346127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11430862/
Abstract

PURPOSE: Breast cancer is a significant global health issue, contributing to 15% of cancer-related deaths. Our laboratory has pioneered a novel approach, combining Ayurvedic principles with green nanotechnology, to develop a scientifically rigorous medical modality referred to as Nano-Ayurvedic Medicine, recently approved by the US Patents and Trademarks Office. Here in we report a new Nano-Ayurvedic medicine agent derived from gold nanoparticles encapsulated with phytochemicals from plant (GB-AuNPs). METHODS: We have developed biocompatible gold nanoparticles using electron-rich phytochemicals from as reducing agent cocktail. phytochemical-encapsulated gold nanoparticles (GB-AuNPs) were fully characterized, and their anticancer activity, including immunomodulatory profiles, were evaluated against breast (MDAMB-231) cancer cell lines. RESULTS: Characterization revealed spherical morphology for GB-AuNPs and possessed optimum in vitro stability through high zeta potential of -34 mV for optimum in vivo stability. The core size of GB-AuNPs of 19 nm allows for penetration into tumor cells through both EPR effects as well as through the receptor-mediated endocytosis. The Antitumor efficacy of this nano-ayurvedic medicine agent revealed strong antitumor effects of GB-AuNPs towards MDAMB-231. Our investigations reveal that GB-AuNPs enhance anti-tumor cytokines (IL-12, TNF-α, IFN-γ) and reduce pro-tumor cytokines (IL-10, IL-6), promoting the conversion of protumor M2 macrophages into M1-like macrophage antitumor phenotype. Cellular studies show that GB-AuNPs offer superior anti-tumor efficacy and a better safety profile against breast tumors compared to cisplatin. CONCLUSION: Our investigations have demonstrated that the nano-ayurvedic medicine agent, GB-AuNPs, treats cancers through an immunomodulatory mechanism facilitated by elevated levels of anti-tumor cytokines (TNF-α, IFN-γ and IL-12) with concomitant downregulation of pro-tumor cytokines expression (IL-6 and IL-10). The green nanotechnology approach for the development of nano-ayurvedic medicine agent (GB-AuNPs), as described in this paper, presents new and attractive opportunities for treating human cancers and other debilitating diseases and disorders.

摘要

目的：乳腺癌是一个重大的全球健康问题，占癌症相关死亡人数的15%。我们实验室开创了一种新颖的方法，将阿育吠陀原则与绿色纳米技术相结合，开发出一种科学严谨的医学模式，称为纳米阿育吠陀医学，最近已获美国专利商标局批准。在此，我们报告一种新的纳米阿育吠陀药物制剂，它由包裹着植物源植物化学物质的金纳米颗粒（GB - AuNPs）制成。 方法：我们使用富含电子的植物源植物化学物质作为还原剂鸡尾酒，开发出了生物相容性金纳米颗粒。对植物化学物质包裹的金纳米颗粒（GB - AuNPs）进行了全面表征，并针对乳腺癌（MDAMB - 231）细胞系评估了它们的抗癌活性，包括免疫调节谱。 结果：表征显示GB - AuNPs呈球形形态，通过 - 34 mV的高zeta电位具有最佳的体外稳定性，以实现最佳的体内稳定性。GB - AuNPs的核心尺寸为19纳米，可通过增强的渗透滞留效应（EPR效应）以及受体介导的内吞作用穿透肿瘤细胞。这种纳米阿育吠陀药物制剂的抗肿瘤功效显示GB - AuNPs对MDAMB - 231具有强大的抗肿瘤作用。我们的研究表明，GB - AuNPs可增强抗肿瘤细胞因子（IL - 12、TNF -α、IFN -γ）并减少促肿瘤细胞因子（IL - 10、IL - 6），促使促肿瘤M2巨噬细胞转化为M1样巨噬细胞抗肿瘤表型。细胞研究表明，与顺铂相比，GB - AuNPs对乳腺肿瘤具有更优的抗肿瘤功效和更好的安全性。 结论：我们的研究表明，纳米阿育吠陀药物制剂GB - AuNPs通过抗肿瘤细胞因子（TNF -α、IFN -γ和IL - 12）水平升高伴随促肿瘤细胞因子表达下调（IL - 6和IL - 10）所促进的免疫调节机制来治疗癌症。本文所述的用于开发纳米阿育吠陀药物制剂（GB - AuNPs）的绿色纳米技术方法，为治疗人类癌症及其他使人衰弱的疾病和病症提供了新的且有吸引力的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b19a/11430862/e504fd9799da/NSA-17-189-g0015.jpg
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