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幽门螺杆菌引起的胃炎患病率及尿素酶试验与血清学(酶联免疫吸附测定)试验相关性的研究

Study of Prevalence of Gastritis Caused by and Correlation of Urease Test with Serology (ELISA) Test.

作者信息

Ranjan Maitreyi, Hameed Hany, Jain Shailesh, Garg Yogesh, Singh Roli, Tyagi Manjulika, Jain Romesh

机构信息

Department of Microbiology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India.

Department of Orthopaedics, Dr. SMCSI Medical College, Trivandrum, Kerala, India.

出版信息

J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2081-S2084. doi: 10.4103/jpbs.jpbs_35_24. Epub 2024 Apr 3.

Abstract

INTRODUCTION

are a pathogen of global importance. Gram-negative curved flagellate bacilli are implicated as one of the most trivial complaints of and are associated with peptic ulcer disease gastritis ulcer and gastric malignancy. This study was performed to find out the prevalence of () infection in patients presenting the symptoms related with gastritis with or without chemically known peptic ulcer.

MATERIALS AND METHODS

The study was undertaken with the help of the Christensen and quotes urease test on endoscopic biopsy specimen and correlated with the detection of immunoglobulin IgG in the serum against by an ELISA technique.

RESULTS

A total of 67 cases were analyzed in which 29 (43%) cases were positive for . The endoscopic findings of acid peptic diseases show 21 (31.4%) cases of stomach ulcer, and 3 (4.5%) have esophagitis, whereas 43 (64.1%) have nonulcer dyspepsia. There is strong positive association between the urease tesr and ELISA test.

CONCLUSION

The urease test is a quick and inexpensive test with high specificity and sensitivity, but since it is an invasive test, it has reduced patient compliance.

摘要

引言

是一种具有全球重要性的病原体。革兰氏阴性弯曲鞭毛杆菌被认为是最常见的病因之一,与消化性溃疡病、胃炎、溃疡和胃癌有关。本研究旨在查明出现与胃炎相关症状(无论是否有已知的化学性消化性溃疡)的患者中()感染的患病率。

材料与方法

本研究借助克里斯滕森法并对内镜活检标本进行尿素酶试验,并通过酶联免疫吸附测定技术将其与血清中针对的免疫球蛋白IgG的检测结果相关联。

结果

共分析了67例病例,其中29例(43%)检测呈阳性。酸相关性疾病的内镜检查结果显示,有21例(31.4%)胃溃疡病例,3例(4.5%)有食管炎,而43例(64.1%)有非溃疡性消化不良。尿素酶试验和酶联免疫吸附测定试验之间存在强正相关。

结论

尿素酶试验是一种快速且廉价的检测方法,具有高特异性和敏感性,但由于它是一种侵入性检测,患者的依从性较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cefe/11426734/34679dcfe1e0/JPBS-16-2081-g001.jpg

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