Janardhan Karthika, Parikh Hiral
Department of Periodontics, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India.
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2655-S2657. doi: 10.4103/jpbs.jpbs_388_24. Epub 2024 Jul 31.
Targeted and efficient therapy strategies are necessary to address the global threat that chronic periodontitis poses to oral health. Antibiotic resistance is one drawback of traditional methods like scaling and root planing in conjunction with systemic antibiotics.
A study with 120 people who had been diagnosed with chronic periodontitis was done using randomized controlled trials. The subjects were grouped as the Feracrylum group and the placebo group. Clinical measures were measured at baseline and again after 12 weeks. These parameters included gingival index, clinical attachment level, and "probing pocket depth (PD)." A 3% solution was locally applied to periodontal pockets in the Feracrylum group, whereas a saline solution was given to the placebo group.
As compared with other cohorts, the Feracrylum group showed a substantial improvement in clinical attachment level and a significant decrease in PD ( < 0.05). Although not statistically significant, the gingival index reduction in the Feracrylum group showed a tendency in the direction of better gingival health.
In summary, feracrylum has the potential as a localized medication delivery adjunct for chronic periodontitis, leading to positive clinical results. Larger sample numbers and longer follow-up times are required for future studies to confirm these results and maximize the use of feracrylum in periodontal treatment.
慢性牙周炎对口腔健康构成全球性威胁，因此需要有针对性且高效的治疗策略。抗生素耐药性是诸如龈下刮治和根面平整联合全身使用抗生素等传统方法的一个缺点。
采用随机对照试验对120名被诊断为慢性牙周炎的患者进行了一项研究。受试者被分为Feracrylum组和安慰剂组。在基线时以及12周后再次测量临床指标。这些参数包括牙龈指数、临床附着水平和“探诊深度（PD）”。Feracrylum组在牙周袋局部应用3%的溶液，而安慰剂组给予盐溶液。
与其他队列相比，Feracrylum组的临床附着水平有显著改善，PD显著降低（<0.05）。虽然无统计学意义，但Feracrylum组牙龈指数的降低显示出牙龈健康状况改善的趋势。
总之，Feracrylum有潜力作为慢性牙周炎的局部药物递送辅助剂，从而产生积极的临床效果。未来的研究需要更大的样本量和更长的随访时间来证实这些结果，并最大限度地在牙周治疗中使用Feracrylum。
