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使用1:80,000肾上腺素局部麻醉与使用1:200,000肾上腺素局部麻醉时患者心血管变化的比较。

Comparison of Cardiovascular Changes Seen in Patients When Using Local Anesthesia with Adrenalin 1:80,000 vs Local Anesthesia with Adrenalin 1:2,00,000.

作者信息

Venkateshwar Gokul, Nayan Swapna, Patil Tejal R, Madiwale Gargi, Dahiya Sarthak, Nair Aishwarya

机构信息

Department of OMFS, DY Patil University School of Dentistry, Navi Mumbai, Maharashtra, India.

Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Navi Mumbai, Maharashtra, India.

出版信息

J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2558-S2562. doi: 10.4103/jpbs.jpbs_391_24. Epub 2024 Jul 31.

DOI:10.4103/jpbs.jpbs_391_24
PMID:39346227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11426899/
Abstract

AIM

The aim of this study is to compare the efficacy with the use of 2% lignocaine with adrenalin with two different concentrations and also its effect on the cardiovascular system.

MATERIALS AND METHODS

100 patients were taken for this study. 68 were Male & 32 females. Extractions of mandibular bilateral teeth (Molars and Pre Molars).2% lignocaine with two different concentrations - one with 1:80000 and the other with 1:200000. Irrespective of the number of teeth extracted, inferior alveolar and lingual nerve blocks were administered (long buccal whenever necessary). Unilateral extractions were carried out in a single sitting and the other side was done on next visit. A single operator carried out all the cases. All the patients were given the same pre-operative and post-operative instructions. A total of 4ml solution was injected on each side.

RESULTS

Systolic blood pressure, pulse rate, onset of anesthesia, durationnof anesthesia and blood loss all the parameter were significant woth p value less tan 0.05.

CONCLUSION

In accordance to our study, 2% lignocaine in 1:2,00,000 dilution of adrenaline can safely be used in minor oral surgical procedures, and is safe in hypertensive and cardiac patients as this dilution does not alter any haemodynamic parameters to a great extent.

摘要

目的

本研究旨在比较两种不同浓度的含肾上腺素的2%利多卡因的疗效及其对心血管系统的影响。

材料与方法

本研究选取了100例患者。其中男性68例，女性32例。进行下颌双侧牙齿（磨牙和前磨牙）拔除术。使用两种不同浓度的2%利多卡因——一种为1:80000，另一种为1:200000。无论拔牙数量多少，均实施下牙槽神经和舌神经阻滞（必要时行颊长神经阻滞）。单侧拔牙在一次就诊时完成，另一侧在下次就诊时进行。所有病例均由单一操作者完成。所有患者均给予相同的术前和术后指导。每侧注射总量为4ml溶液。

结果

收缩压、脉搏率、麻醉起效时间、麻醉持续时间和失血量等所有参数均具有显著性，p值小于0.05。

结论

根据我们的研究，1:200000稀释度肾上腺素的2%利多卡因可安全用于小型口腔外科手术，对高血压和心脏病患者也安全，因为这种稀释度不会在很大程度上改变任何血流动力学参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/6105a66145ae/JPBS-16-2558-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/0133687277f2/JPBS-16-2558-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/967bfdd1c5bd/JPBS-16-2558-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/f682440cf3ce/JPBS-16-2558-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/c49304993242/JPBS-16-2558-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/2a3da17c21ac/JPBS-16-2558-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/6105a66145ae/JPBS-16-2558-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/0133687277f2/JPBS-16-2558-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/967bfdd1c5bd/JPBS-16-2558-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/f682440cf3ce/JPBS-16-2558-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/c49304993242/JPBS-16-2558-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/2a3da17c21ac/JPBS-16-2558-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14b9/11426899/6105a66145ae/JPBS-16-2558-g006.jpg

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