Hanvold K I, Vigen E C, Jorkjend L, Aass A M, Skoglund L A
Section of Dental Pharmacology and Pharmacotherapy, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Norway.
Private Practitioner in Periodontology, Skien, Norway.
Br J Oral Maxillofac Surg. 2008 Apr;46(3):218-222. doi: 10.1016/j.bjoms.2007.10.004. Epub 2007 Dec 3.
A randomised, single-blind, within-patient, crossover study was done in 45 patients (29 women and 16 men, mean age 49 years, range 37-71) who had bilateral "identical" gingivectomies. On one occasion a standard volume of local anaesthetic containing 2% lidocaine and 1/80,000 adrenaline was infiltrated into the mucosal tissue before operation. On the other, double the standard volume with 1% lidocaine and 1/160,000 adrenaline was infiltrated. The intensity of postoperative pain was recorded by the patients on a 100 mm visual analogue scale every hour for an 11-hour observation period. The time courses and the sum of pain intensity after injection of the double and standard volumes did not differ significantly. Doubling the volume of local anaesthetic while maintaining the total lidocaine and adrenaline concentration that was infiltrated does not influence the intensity of acute pain after gingivectomy.
对45例患者（29名女性和16名男性，平均年龄49岁，范围37 - 71岁）进行了一项随机、单盲、患者自身对照的交叉研究，这些患者均接受了双侧“相同”的牙龈切除术。一次是在手术前将含有2%利多卡因和1/80,000肾上腺素的标准剂量局部麻醉药注入黏膜组织。另一次是注入两倍标准剂量、含1%利多卡因和1/160,000肾上腺素的局部麻醉药。在11小时的观察期内，患者每小时用100毫米视觉模拟量表记录术后疼痛强度。注入两倍剂量和标准剂量后的疼痛强度随时间变化情况及疼痛强度总和无显著差异。在维持利多卡因和肾上腺素总浓度不变的情况下，将局部麻醉药剂量加倍不会影响牙龈切除术后的急性疼痛强度。
