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Genetic basis of molecular mechanisms in β-lactam resistant gram-negative bacteria.β-内酰胺类耐药革兰氏阴性菌中分子机制的遗传基础。
Microb Pathog. 2021 Sep;158:105040. doi: 10.1016/j.micpath.2021.105040. Epub 2021 Jun 10.
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: Prevalence, Reservoirs, Antimicrobial Resistance, Pathogenicity, and Infection: A Hitherto Unrecognized Zoonotic Bacterium.: 流行状况、储存宿主、耐药性、致病性和感染：一种迄今未被识别的人畜共患病细菌。
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The Characteristic of Virulence, Biofilm and Antibiotic Resistance of .肠球菌的毒力特性、生物膜形成能力和抗生素耐药性。
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Antimicrobial Resistance of Hypervirulent : Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms.高毒力 耐药性：流行病学、高毒力相关决定因素和耐药机制。
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Clinical Implications of Genomic Adaptation and Evolution of Carbapenem-Resistant Klebsiella pneumoniae.耐碳青霉烯类肺炎克雷伯菌基因组适应与进化的临床意义
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High Prevalence of ESBL-Producing Causing Community-Onset Infections in China.在中国，产超广谱β-内酰胺酶细菌引起社区获得性感染的患病率较高。
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糖尿病足溃疡（DFU）产超广谱β-内酰胺酶（ESBL）和金属β-内酰胺酶（MBL）的基因特征分析

Genetic Characterization of Extended-Spectrum Beta-Lactamase (ESBL) and Metallo-Beta-Lactamase (MBL) Producing from Diabetic Foot Ulcer (DFU).

作者信息

Kale Dipak S, Karande Geeta S, Kale Kalpana D, Patil Satish R, Datkhile Kailas D

机构信息

Department of Microbiology, Krishna Vishwa Vidyapeeth "Deemed to be University", Dist-Satara, Maharashtra, India.

Department of Pathology, Kale Pathology Laboratory, Dist-Satara, Maharashtra, India.

出版信息

J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2524-S2526. doi: 10.4103/jpbs.jpbs_349_24. Epub 2024 Jul 31.

DOI:10.4103/jpbs.jpbs_349_24
PMID:39346272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11426622/
Abstract

BACKGROUND

Antibiotic resistance in common pathogenic bacteria is linked with the genetic makeup. The genetic basis of antibiotic resistance may vary in different species or pathophysiological conditions.

OBJECTIVES

We studied the antibiotic resistance in isolates from DFU in the western Indian population. We also studied the presence of ESBL and MBL mechanisms of antibiotic resistance along with the prevalence of the genes involved in ESBL (TEM , SHV , and CTX-M ) and MBL (NDM-1 , KPC , OXA-48 , and VIM ) production.

RESULTS

A total of 161 isolates were analyzed; among which 50.93% were positive for ESBL and 45.96% were positive for MBL production. Most of the isolates were resistant to antibiotics used in the present study and partially resistant to Imipenem and Amikacin. There was no relation between the antibiotic resistance of the isolates and the production of ESBL or MBL mechanism of antibiotic resistance. Further, TEM was the most prevalent gene in isolates followed by CTX-M , NDM-1 , SHV , and KPC . VIM was the least prevalent gene found in isolates. There was no difference in the prevalence of the genes with respect to the presence or absence of ESBL and MBL mechanism of resistance. Further, there was no relation between the prevalence of the genes and antibiotic resistance in isolates.

CONCLUSION

These results along with the literature review suggest that the prevalence of the genes involved in antibiotic resistance mechanisms are widespread in India and their distribution varies in different studies.

摘要

背景

常见病原菌中的抗生素耐药性与基因构成有关。抗生素耐药性的遗传基础在不同物种或病理生理条件下可能有所不同。

目的

我们研究了印度西部人群中糖尿病足溃疡（DFU）分离株的抗生素耐药性。我们还研究了超广谱β-内酰胺酶（ESBL）和金属β-内酰胺酶（MBL）抗生素耐药机制的存在情况，以及参与ESBL（TEM、SHV和CTX-M）和MBL（NDM-1、KPC、OXA-48和VIM）产生的基因的流行情况。

结果

共分析了161株分离株；其中50.93%的菌株ESBL检测呈阳性，45.96%的菌株MBL检测呈阳性。大多数分离株对本研究中使用的抗生素耐药，对亚胺培南和阿米卡星部分耐药。分离株的抗生素耐药性与ESBL或MBL抗生素耐药机制的产生之间没有关系。此外，TEM是分离株中最常见的基因，其次是CTX-M、NDM-1、SHV和KPC。VIM是分离株中最不常见的基因。就ESBL和MBL耐药机制的存在与否而言，基因的流行率没有差异。此外，基因的流行率与分离株中的抗生素耐药性之间没有关系。

结论

这些结果以及文献综述表明，参与抗生素耐药机制的基因在印度广泛存在，其分布在不同研究中有所不同。