Alam Mohammad Khursheed, Alfuhigi Mashael Zaid, Hajeer Mohammad Younis, Alrubaysh Mohammed Abdullah, Alslai Moath Ahmad, Alsabilah Abdulmajeed Fehaid
Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka, Saudi Arabia.
Department of Dental Research Cell, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India.
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2512-S2514. doi: 10.4103/jpbs.jpbs_325_24. Epub 2024 Jun 8.
Orthodontic treatment involves the use of various materials, including brackets and wires, which come into direct contact with oral tissues. Biocompatibility of these materials is crucial to ensure patient safety and treatment success. This study aims to evaluate the biocompatibility of orthodontic brackets and wires through an in-vitro investigation.
Orthodontic brackets and wires commonly used in clinical practice were selected for this study. A series of in-vitro tests were conducted to assess the biocompatibility of these materials. Cell culture assays were performed to evaluate cytotoxicity, cell proliferation, and inflammatory response. In addition, scanning electron microscopy (SEM) was used to examine the surface characteristics of the materials.
The cytotoxicity assays revealed minimal adverse effects on cell viability, with cell viability percentages ranging from 90% to 95% for all materials tested. Cell proliferation assays demonstrated similar rates of cell growth on the surfaces of both brackets and wires. SEM analysis indicated smooth surfaces with minimal irregularities, suggesting favorable biocompatibility.
The findings of this in-vitro study suggest that the orthodontic brackets and wires examined exhibit satisfactory biocompatibility characteristics. Minimal cytotoxicity and favorable cell proliferation indicate that these materials are well suited for use in orthodontic treatment. Further clinical studies are warranted to validate these findings and ensure the safety and efficacy of orthodontic appliances in patient care.
正畸治疗涉及使用各种材料，包括托槽和弓丝，这些材料会与口腔组织直接接触。这些材料的生物相容性对于确保患者安全和治疗成功至关重要。本研究旨在通过体外研究评估正畸托槽和弓丝的生物相容性。
本研究选择了临床实践中常用的正畸托槽和弓丝。进行了一系列体外测试以评估这些材料的生物相容性。进行细胞培养试验以评估细胞毒性、细胞增殖和炎症反应。此外，使用扫描电子显微镜（SEM）检查材料的表面特征。
细胞毒性试验显示对细胞活力的不良影响极小，所有测试材料的细胞活力百分比在90%至95%之间。细胞增殖试验表明托槽和弓丝表面的细胞生长速率相似。SEM分析表明表面光滑，不规则之处极少，表明生物相容性良好。
这项体外研究的结果表明，所检查的正畸托槽和弓丝具有令人满意的生物相容性特征。极小的细胞毒性和良好的细胞增殖表明这些材料非常适合用于正畸治疗。有必要进行进一步的临床研究以验证这些发现，并确保正畸矫治器在患者护理中的安全性和有效性。
