Chakrabarty Ushnish, Yadav Surendra S, Datta Swarnendu
Department of Cardio-Thoracic and Vascular Surgery, Medical College and Hospital, Kolkata, West Bengal, India.
Department of Cardio-Thoracic and Vascular Surgery, AIIMS, Bhopal, Madhya Pradesh, India.
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2215-S2217. doi: 10.4103/jpbs.jpbs_158_24. Epub 2024 Apr 24.
The aim of this study was to find out the relationship of conventional and/or novel cardiovascular risk factors with coronary artery disease severity in terms of SYNTAX scores in young (≤45 years) and aged (>45 years) patients.
The final number of patients included in the study was 132 and divided into 2 groups: Group A was young patients with age less than 45 years, and in group B, the age was more than 45 years. The SYNTAX score was determined for each case based on the preoperative coronary angiogram using the Online SYNTAX score calculator version 2.11.
It was seen that 33% of patients in group A had high SYNTAX scores, as compared to only 8% in group B. This definitely shows that the younger population has more COMPLEX coronary artery lesions than the elderly.
YOUNG patients have significantly higher levels of homocysteine as compared to the elderly. Serum homocysteine correlates with SYNTAX scores in YOUNG patients, with a sensitivity of 83.33%, specificity 91.67%, and diagnostic accuracy 86.67%. Percentage of Low HDL in YOUNG is significantly higher than in the elderly.
本研究旨在根据Syntax评分，探究年轻（≤45岁）和老年（>45岁）患者中传统和/或新型心血管危险因素与冠状动脉疾病严重程度之间的关系。
本研究纳入的患者最终数量为132例，分为两组：A组为年龄小于45岁的年轻患者，B组年龄大于45岁。使用在线Syntax评分计算器2.11版，根据术前冠状动脉造影为每个病例确定Syntax评分。
结果显示，A组33%的患者Syntax评分较高，而B组仅为8%。这明确表明，年轻人群比老年人群具有更复杂的冠状动脉病变。
与老年人相比，年轻患者的同型半胱氨酸水平显著更高。年轻患者血清同型半胱氨酸与Syntax评分相关，敏感性为83.33%，特异性为91.67%，诊断准确性为86.67%。年轻患者中低高密度脂蛋白的比例显著高于老年人。
