L-苏糖型二羟基苯丝氨酸对大鼠脑内去甲肾上腺素代谢的影响。

The effects of L-threo-dihydroxyphenylserine on norepinephrine metabolism in rat brain.

作者信息

Semba J, Takahashi R

出版信息

Psychiatry Res. 1985 Aug;15(4):319-26. doi: 10.1016/0165-1781(85)90069-1.

Abstract

The effects of L-threo-3,4-dihydroxyphenylserine (DOPS), an artificial precursor of norepinephrine (NE), on NE metabolism in rat brain were investigated. DOPS administration resulted in a significant elevation in cerebral NE and 3-methoxy-4-hydroxyphenylglycol contents, while carbidopa pretreatment completely blocked these increases. After brain NE was depleted by either alpha-methyl-p-tyrosine (AMPT), fusaric acid, FLA-63, or reserpine, NE restoration by DOPS was observed in rats treated with either fusaric acid or chronic reserpine. No NE restoration was observed after pretreatment with AMPT, FLA-63, or acute reserpine. The results suggest that NE formed after DOPS administration is mainly localized in the brain capillaries. In some NE-depleting conditions, however, DOPS can penetrate the brain parenchyma.

摘要

研究了去甲肾上腺素（NE）的人工前体L-苏式-3,4-二羟基苯丝氨酸（DOPS）对大鼠脑内NE代谢的影响。给予DOPS后，脑内NE和3-甲氧基-4-羟基苯乙二醇含量显著升高，而卡比多巴预处理可完全阻断这些升高。在用α-甲基-p-酪氨酸（AMPT）、镰刀菌酸、FLA-63或利血平使脑内NE耗竭后，在用镰刀菌酸或慢性利血平处理的大鼠中观察到DOPS使NE恢复。用AMPT、FLA-63或急性利血平预处理后未观察到NE恢复。结果表明，给予DOPS后形成的NE主要定位于脑毛细血管。然而，在某些NE耗竭情况下，DOPS可穿透脑实质。