DL-苏式-3,4-二羟基苯丝氨酸（DOPS）对人类柯萨科夫综合征的记忆效应。

Memory effect of DL-threo-3,4-dihydroxyphenylserine (DOPS) in human Korsakoff's disease.

作者信息

Langlais P J, Mair R G, Whalen P J, McCourt W, McEntee W J

机构信息

Research Service, Veterans Administration Medical Center, Brockton, MA 02401.

出版信息

Psychopharmacology (Berl). 1988;95(2):250-4. doi: 10.1007/BF00174518.

DOI:10.1007/BF00174518

PMID:3137605

Abstract

A group of amnesic patients with Korsakoff's disease were treated with a single 1 g dose of DL-threo-3,4-dihydroxyphenylserine (DOPS) and placebo (lactose) in a double-blind crossover study. Three hours following administration, patients were given a battery of psychometric tests to determine the effects of the treatment on memory functions. Administration of DOPS had a significant effect on performance on the Memory Passages test but not on any of the other measures of memory. The effect of DOPS on Memory Passages is similar to the response observed following administration of clonidine in Korsakoff patients. Blood pressure and pulse, measured before and every 2 h after treatment, were unaffected by DOPS.

摘要

在一项双盲交叉研究中，一组患有科尔萨科夫综合征的失忆患者接受了单次1克剂量的DL-苏式-3,4-二羟基苯丝氨酸（DOPS）和安慰剂（乳糖）治疗。给药三小时后，对患者进行了一系列心理测量测试，以确定治疗对记忆功能的影响。DOPS给药对记忆段落测试的表现有显著影响，但对其他任何记忆指标均无影响。DOPS对记忆段落的影响与在科尔萨科夫患者中给予可乐定后观察到的反应相似。治疗前及治疗后每2小时测量的血压和脉搏不受DOPS影响。