Zhao Guo-Hong, Wang Jin-Da, Liu Mei-Rui, Zhang Li-Jun, Sun Yan, Cao Kai
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.
Department of Pulmonary Rehabilitation, Emergency General Hospital, Beijing, People's Republic of China.
Clin Ophthalmol. 2024 Sep 24;18:2697-2704. doi: 10.2147/OPTH.S475970. eCollection 2024.
To explore the distribution and influence factors of non-invasive tear film break-up time (NIBUT) in children.
This is a hospital-based cross-sectional study. Spherical equivalent error (SER) was measured with cycloplegia. NIBUT was measured by an ocular surface integrated analyzer.
A total of 1269 children (1269 eyes) were included in this study. Participants' median age was 11 (range 6-18) years. 47.1% (598/1269) of participants were boys. The median NIBUT of myopic children and non-myopic children were 9.9 seconds (s) (Inter-quartile range, IQR: 6.4 to 16.1) and 10.9 s (IQR: 8.8 to 17.9), respectively, which was statistically significant (p = 0.004). In myopic children, 49.9% (573/1148) were able to achieve NIBUT of 10 s or more, compared to 67.8% (82/121) in non-myopic children, which was statistically significant (p < 0.001). There were 41 (3.57%) children in the myopic group and none (0%) in the non-myopic group with dry eye disease (p = 0.028). There was a positive correlation between NIBUT and age: NIBUT = 9.256 + 0.352*Age. 71.8% (824/1148) of myopic children used electronic products almost every day, compared to 37.2% (45/121) of non-myopic children, which was statistically significant (p < 0.001).
The NIBUT of myopic children was significantly shorter than that of non-myopic children. Children with myopia are more likely to have dry eyes. NIBUT increases with age. High frequency of electronic product use may be an important cause to NIBUT shortening in children.
探讨儿童非侵入性泪膜破裂时间（NIBUT）的分布及影响因素。
这是一项基于医院的横断面研究。使用睫状肌麻痹剂测量等效球镜度误差（SER）。通过眼表综合分析仪测量NIBUT。
本研究共纳入1269名儿童（1269只眼）。参与者的年龄中位数为11岁（范围6 - 18岁）。47.1%（598/1269）的参与者为男孩。近视儿童和非近视儿童的NIBUT中位数分别为9.9秒（四分位间距，IQR：6.4至16.1）和10.9秒（IQR：8.8至17.9），差异有统计学意义（p = 0.004）。在近视儿童中，49.9%（573/1148）的NIBUT能够达到10秒或更长时间，而非近视儿童中这一比例为67.8%（82/121），差异有统计学意义（p < 0.001）。近视组有41名（3.57%）儿童患有干眼症，非近视组无（0%），差异有统计学意义（p = 0.028）。NIBUT与年龄呈正相关：NIBUT = 9.256 + 0.352×年龄。71.8%（824/1148）的近视儿童几乎每天使用电子产品，而非近视儿童中这一比例为37.2%（45/121），差异有统计学意义（p < 0.001）。
近视儿童的NIBUT明显短于非近视儿童。近视儿童更易患干眼症。NIBUT随年龄增长而增加。频繁使用电子产品可能是儿童NIBUT缩短的重要原因。
