Vaid Savya, Rajashekhar Rashmi P, Shah Heer, Babu Manu, Moruskar Aditi S
Otolaryngology - Head and Neck Surgery, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Microbiology, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Cureus. 2024 Aug 28;16(8):e67989. doi: 10.7759/cureus.67989. eCollection 2024 Aug.
Background Chronic otitis media (COM) is a persistent inflammatory condition of the middle ear and mastoid cavity, characterized by otorrhea and a perforated tympanic membrane. The microbial agents associated with COM vary over time and by geographic location. According to the WHO classification of countries based on COM prevalence, India is classified as having the highest prevalence (>4%) due to a national average of 7.8%, with the majority of the burden affecting individuals in lower socioeconomic strata. Objectives The objective of this study is to analyze the bacterial profile and antibiotic susceptibility patterns of isolates in patients with COM and to examine the age and gender distribution of these patients. Methods A cross-sectional microbiological study was conducted in the Department of Otorhinolaryngology at Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University), Pune, India, from January 2023 to March 2023. The sample size was determined using WinPepi software. A total of 30 samples were collected from patients aged 5-15 years with active COM who presented to the ENT OPD. Patients who had been treated with antibiotics in the 15 days prior to the study were excluded. Results Of the 30 patients, most were in the age groups of 16-25 years (36.67%) and 26-35 years (16.67%), with only 10% in the 5-15 years age group. The age range of participants was eight to 55 years, with a mean age of 27 years. There was a gender disparity in the distribution of COM, with males representing 56.67% and females 43.33%, resulting in a male-to-female ratio of 1.3:1. The majority of patients had mucosal COM (24/30, 80%), while the remaining had squamosal COM (6/30, 20%). was isolated in 24 samples (80%), and was identified in six samples (20%). Conclusion In the Indian context, where many predisposing factors for COM are prevalent, the disease remains highly common and can lead to severe complications if not treated promptly. This study analyzed ear swabs from 30 patients diagnosed with COM. The results revealed that was the most common microorganism, followed by . The most effective antibiotics against were piperacillin-tazobactam, ceftazidime, and meropenem. For , the most effective antibiotics included teicoplanin, vancomycin, linezolid, and cotrimoxazole.
背景 慢性中耳炎（COM）是中耳和乳突腔的一种持续性炎症性疾病，其特征为耳漏和鼓膜穿孔。与COM相关的微生物病原体随时间和地理位置而有所不同。根据世界卫生组织基于COM患病率对各国的分类，印度被归类为患病率最高（>4%）的国家，因为其全国平均患病率为7.8%，且大多数负担影响社会经济地位较低阶层的个体。目的 本研究的目的是分析COM患者分离株的细菌谱和抗生素敏感性模式，并研究这些患者的年龄和性别分布。方法 2023年1月至2023年3月，在印度浦那的迪帕克·帕蒂尔医学学院、医院及研究中心（迪帕克·帕蒂尔维迪佩特，被视为大学）的耳鼻喉科进行了一项横断面微生物学研究。使用WinPepi软件确定样本量。共从5至15岁患有活动性COM并就诊于耳鼻喉科门诊的患者中收集了30份样本。排除在研究前15天内接受过抗生素治疗的患者。结果 在这30名患者中，大多数处于16至25岁年龄组（36.67%）和26至35岁年龄组（16.67%），5至15岁年龄组仅占10%。参与者的年龄范围为8至55岁，平均年龄为27岁。COM的分布存在性别差异，男性占56.67%，女性占43.33%，男女比例为1.3:1。大多数患者患有黏膜性COM（24/30，80%），其余患者患有鳞状上皮性COM（6/30，20%）。在24份样本（80%）中分离出了[具体细菌1]，在6份样本（20%）中鉴定出了[具体细菌2]。结论 在印度，许多COM的诱发因素普遍存在，这种疾病仍然非常常见，如果不及时治疗可能会导致严重并发症。本研究分析了30例诊断为COM的患者的耳拭子。结果显示[具体细菌1]是最常见的微生物，其次是[具体细菌2]。针对[具体细菌1]最有效的抗生素是哌拉西林-他唑巴坦、头孢他啶和美罗培南。对于[具体细菌2]，最有效的抗生素包括替考拉宁、万古霉素、利奈唑胺和复方新诺明。
