Bash Gina N, Chung Jina, Fett Nicole
Department of Dermatology, Oregon Health & Science University, Portland, USA.
Department of Dermatology, University of Pennsylvania, Philadelphia, USA.
Cureus. 2024 Aug 28;16(8):e68061. doi: 10.7759/cureus.68061. eCollection 2024 Aug.
Dupilumab has recently been recognized as a potential trigger for drug-induced sarcoid-like reactions (DISR). This phenomenon may become more prevalent with increased utilization of this drug for a multitude of skin and atopic conditions. We present a unique case of a patient developing a solitary cutaneous nodule on her left forearm following dupilumab initiation. Histopathology and MRI studies confirmed that this nodule had features of a sarcoid granuloma. Six months following dupilumab discontinuation, the patient's granuloma resolved. This case demonstrates that dupilumab can induce cutaneous-limited autoimmune disease and stresses the importance of prompt recognition of dupilumab-induced sarcoid-like reactions for appropriate diagnosis and treatment.
度普利尤单抗最近被认为是药物性结节病样反应（DISR）的一个潜在触发因素。随着这种药物在多种皮肤和特应性疾病中的使用增加，这种现象可能会变得更加普遍。我们报告了一例独特的病例，一名患者在开始使用度普利尤单抗后，左前臂出现了一个孤立的皮肤结节。组织病理学和MRI研究证实，这个结节具有结节病肉芽肿的特征。在停用度普利尤单抗6个月后，患者的肉芽肿消退。该病例表明，度普利尤单抗可诱发皮肤局限性自身免疫性疾病，并强调了及时识别度普利尤单抗诱发的结节病样反应对于正确诊断和治疗的重要性。
