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血液透析导管相关血流感染病因:两例报告及文献复习

Hemodialysis Catheter-Related Bloodstream Infection Caused by : Report of Two Cases and Literature Review.

作者信息

Wang Xiuri, Liang Yunxiao, Hu Liuyang

机构信息

Department of Gastroenterology, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530016, People's Republic of China.

Department of Laboratory Medicine, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530016, People's Republic of China.

出版信息

Infect Drug Resist. 2024 Sep 25;17:4167-4173. doi: 10.2147/IDR.S481733. eCollection 2024.

Abstract

Species of are mainly environmental strains and plant pathogens, rarely causing human infections. Here, we describe two cases of hemodialysis catheter-related bloodstream infection caused by in patients with uremia. To our knowledge, this is the first reported case of catheter related bloodstream infection caused by () in hemodialysis patients, as well as the first case of bloodstream infection caused by (). Multiple blood cultures from the catheter showed the presence of , and the isolated and were found to be highly sensitive to various antibiotics. Prompt use of antibiotics and catheter lock with gentamicin or amikacin led to rapid recovery of the patients, avoiding the economic burden of catheter replacement. Infections caused by might be underestimated as methods such as VITEK MS system often result in misidentification. Therefore, we recommend using advanced techniques such as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) or 16S ribosomal RNA analysis to detect more cases of infections. By sharing these cases, we hope to increase awareness among clinicians about the potential pathogenicity of in hemodialysis patients. It is crucial to strengthen noting the primary concern for sources of infection with species (plant and environmental exposures) to prevent outbreaks of -related bloodstream infections in hospitals.

摘要

[该菌]的菌种主要是环境菌株和植物病原体,很少引起人类感染。在此,我们描述两例尿毒症患者因[该菌]导致的血液透析导管相关血流感染病例。据我们所知,这是首次报道血液透析患者中由[该菌]([具体菌名])引起的导管相关血流感染病例,也是首例由[该菌]引起的血流感染病例。从导管采集的多次血培养显示存在[该菌],分离出的[该菌]对多种抗生素高度敏感。及时使用抗生素并用庆大霉素或阿米卡星进行导管封管,使患者迅速康复,避免了更换导管的经济负担。由于VITEK MS系统等方法常导致错误鉴定,[该菌]引起的感染可能被低估。因此,我们建议使用基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF MS)或16S核糖体RNA分析等先进技术来检测更多[该菌]感染病例。通过分享这些病例,我们希望提高临床医生对[该菌]在血液透析患者中潜在致病性的认识。加强关注[该菌]菌种(植物和环境暴露)的感染源这一主要问题对于预防医院内与[该菌]相关的血流感染暴发至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdde/11439352/0691dd6c2acf/IDR-17-4167-g0001.jpg

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