Zhou Hongyu, Qiu Huiying, Wang Xiaoyue, Zhao Jingyi, Zhang Jingbo, Zhang Yuan, Peng Tingting, Yang Xubo, Cheng Yahui, Hou Qingfen, Yang Wen, Huang Xiaoyin, Qiu Shaihong, Ma Liying, Zheng Yuai, Tang Hongmei, He Lu, Xu Kaishou
Department of Rehabilitation, Guangzhou Women and Children Medical Center Guangzhou Medical University Guangdong China.
Department of rehabilitation Guangdong Provincial Clinical Research Center for Child Health Guangdong China.
Pediatr Investig. 2024 Jul 31;8(3):184-192. doi: 10.1002/ped4.12442. eCollection 2024 Sep.
Nutrition is associated with neurodevelopment. Infants at high risk of cerebral palsy (CP) usually suffer from undernutrition, yet the relationship between nutritional status and neurodevelopmental levels is unclear.
To describe the nutritional status characteristics of infants at high risk of CP, and to explore the relationship between neurodevelopmental levels and nutritional status.
This single-center cross-sectional study enrolled infants at high risk of CP, with corrected age from 0 days to 12 months. Weight and height were measured and calculated into z-scores, which were used to classify the nutritional status based on the World Health Organization growth charts and American Society for Parenteral and Enteral Nutrition standards. The Bayley Scales of Infant and Toddler Development were used to evaluate the developmental levels of gross motor, fine motor, cognition, receptive communication, and expressive communication.
A total of 479 infants at high risk of CP were recruited, with 43.4% classified as undernutrition. Compared to those with normal neurodevelopment, the odds of moderate and severe undernutrition were about 1.8 and 3.9 times higher in gross motor delay, 2.2 and 3.1 times higher in fine motor delay, 2.5 and 9.4 times higher in cognition delay, 2.2 and 3.9 times higher in receptive communication delay, and 3.0 and 5.6 times higher in expressive communication delay. There were significant positive correlations between nutritional status and neurodevelopmental levels ( < 0.001).
Undernutrition and neurodevelopmental delays are prevalent among infants at high risk of CP. Worse nutritional status was correlated with lower neurodevelopmental levels.
营养与神经发育相关。脑瘫（CP）高危婴儿通常存在营养不足的情况，然而营养状况与神经发育水平之间的关系尚不清楚。
描述CP高危婴儿的营养状况特征，并探讨神经发育水平与营养状况之间的关系。
这项单中心横断面研究纳入了CP高危婴儿，矫正年龄从0天至12个月。测量体重和身高并计算成z评分，根据世界卫生组织生长图表和美国肠外肠内营养学会标准对营养状况进行分类。使用贝利婴幼儿发育量表评估大运动、精细运动、认知、接受性沟通和表达性沟通的发育水平。
共招募了479名CP高危婴儿，其中43.4%被归类为营养不足。与神经发育正常的婴儿相比，大运动发育迟缓中、重度营养不足的几率分别高出约1.8倍和3.9倍，精细运动发育迟缓分别高出2.2倍和3.1倍，认知发育迟缓分别高出2.5倍和9.4倍，接受性沟通发育迟缓分别高出2.2倍和3.9倍，表达性沟通发育迟缓分别高出3.0倍和5.6倍。营养状况与神经发育水平之间存在显著正相关（<0.001）。
营养不足和神经发育迟缓在CP高危婴儿中普遍存在。营养状况越差，神经发育水平越低。
