医学辅助生殖（MAR）和妊娠计划对矫正 12 月龄早产儿贝利 III 筛选测试分量表的影响：一项横断面研究。
Effect of medically assisted reproduction (MAR) and pregnancy planning on Bayley-III Screening Test subscales in preterm infants at 12 months of corrected age: a cross-sectional study.
机构信息
Faculty of Medicine, Pediatric Psychology and Psychosomatic Unit of the Department of Pediatrics, Kálmán Laki Doctoral School, University of Debrecen, 98. Nagyerdei Boulevard, 4032, Debrecen, Hungary.
Faculty of Informatics, Department of Applied Mathematics and Probability Theory, University of Debrecen, Debrecen, Hungary.
出版信息
Ital J Pediatr. 2022 May 8;48(1):69. doi: 10.1186/s13052-022-01259-w.
BACKGROUND
The association between medically assisted reproduction and pregnancy planning on overall developmental outcomes of infants has been studied in relatively few studies. The availability of accurate tools for the early detection of developmental delays is a major issue. The purpose of this study is describing the average neurodevelopment of preterm infants and assessing the association between medically assisted reproduction, pregnancy planning and neurodevelopmental outcomes among Hungarian preterm infants.
METHODS
Cross-sectional study of preterm infants with gestational age < 37 weeks (N = 171) who underwent developmental assessment using Bayley-III Screening Test (Bayley Scales of Infant and Toddler Development Screening Test - Third Edition) in five developmental domains (cognitive, receptive and expressive language, fine and gross motor) at 12 months of corrected age. We examined the developmental pattern of infants and the potential associations between medically assisted reproduction, pregnancy planning and Bayley-III Screening Test subscales. Information on the mode of conception and pregnancy planning was obtained through parental anamnesis.
RESULTS
Concerning the risk for developmental delay, the language and motor subscales were the most affected. Examination of the mode of conception and developmental outcomes revealed higher neurodevelopmental skills in infants who were conceived through medically assisted reproduction. Significantly lower cognitive, receptive and expressive language skills were found to be associated with unplanned pregnancies. Multi-way analysis of variance was conducted in order to assess the impact of the mode of conception and pregnancy planning on subscales.
CONCLUSIONS
We cannot unambiguously conclude that MAR and pregnancy planning had a solely positive effect on the development of preterm infants at 12 months of corrected age, but our results are vital for the design and implementation of further research.
背景
医学辅助生殖与妊娠计划对婴儿整体发育结果的关系在相对较少的研究中进行了研究。准确的早期发育迟缓检测工具的可用性是一个主要问题。本研究的目的是描述早产儿的平均神经发育情况，并评估匈牙利早产儿中医学辅助生殖、妊娠计划和神经发育结果之间的关系。
方法
对胎龄<37 周的早产儿进行横断面研究（N=171），在 12 个月的矫正年龄时使用贝利 III 筛查测试（贝利婴幼儿发展筛查测试第三版）对五个发育领域（认知、接受性和表达性语言、精细和粗大运动）进行发育评估。我们检查了婴儿的发育模式以及医学辅助生殖、妊娠计划和贝利 III 筛查测试子量表之间的潜在关联。通过父母病史获得关于受孕方式和妊娠计划的信息。
结果
就发育迟缓的风险而言，语言和运动子量表受影响最大。对受孕方式和发育结果的检查显示，通过医学辅助生殖受孕的婴儿具有更高的神经发育技能。未计划妊娠与认知、接受性和表达性语言技能显著降低有关。进行了多向方差分析，以评估受孕方式和妊娠计划对子量表的影响。
结论
我们不能明确地得出结论，认为 MAR 和妊娠计划对 12 个月矫正年龄的早产儿发育有单纯的积极影响，但我们的结果对进一步研究的设计和实施至关重要。
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