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利用 MALDI-MSI 测定新型前列腺癌组织芯片中 N-糖链和胶原蛋白/细胞外基质蛋白的组成。

Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI.

机构信息

Medical University of South Carolina, Charleston, South Carolina.

University of Texas Health Science Center, San Antonio, Texas.

出版信息

Cancer Res Commun. 2024 Nov 1;4(11):3036-3048. doi: 10.1158/2767-9764.CRC-24-0152.

DOI:10.1158/2767-9764.CRC-24-0152
PMID:39347566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11600299/
Abstract

Using matrix-assisted laser desorption/ionization mass spectrometry imaging techniques on a unique cohort of prostate cancer tissues, we highlighted several molecular characteristics of matrix that have potential to act as early predictors of prostate cancer metastasis.

摘要

利用基质辅助激光解吸/电离质谱成像技术对一组独特的前列腺癌组织进行研究，我们强调了基质的几个分子特征，这些特征有可能成为前列腺癌转移的早期预测因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/457cdb4335ef/crc-24-0152_f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/6281f5b74f24/crc-24-0152_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/ed393b14becf/crc-24-0152_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/30b743cca223/crc-24-0152_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/831207e34a9a/crc-24-0152_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/153e5cdda2eb/crc-24-0152_f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/17186532f828/crc-24-0152_f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/457cdb4335ef/crc-24-0152_f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/6281f5b74f24/crc-24-0152_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/ed393b14becf/crc-24-0152_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/30b743cca223/crc-24-0152_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/831207e34a9a/crc-24-0152_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/153e5cdda2eb/crc-24-0152_f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/17186532f828/crc-24-0152_f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd0/11600299/457cdb4335ef/crc-24-0152_f7.jpg

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J Am Soc Mass Spectrom. 2024 Mar 6;35(3):487-497. doi: 10.1021/jasms.3c00366. Epub 2024 Feb 8.
2
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Targeting aberrant sialylation and fucosylation in prostate cancer cells using potent metabolic inhibitors.
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Glycobiology. 2023 Dec 30;33(12):1155-1171. doi: 10.1093/glycob/cwad085.
4
ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.ST6GAL1 介导的异常唾液酸化促进前列腺癌进展。
J Pathol. 2023 Sep;261(1):71-84. doi: 10.1002/path.6152. Epub 2023 Aug 7.
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