Ren Zhiqiang, Feng Tianhui, Gao Tianli, Han Bo, Guo Ruili, Ma Haojie, Wang Ji-Jiang, Zhang Yuqi
Laboratory of New Energy & New Functional Materials, Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, Yan'an University, Yan'an 716000, P. R. China.
Org Lett. 2024 Oct 11;26(40):8532-8536. doi: 10.1021/acs.orglett.4c03118. Epub 2024 Sep 30.
A Cu(I)-catalyzed highly regioselective synthesis of 2-acetamidequinoline -oxides using dioxazolones with quinoline -oxides has been reported. The reaction possesses mild reaction conditions and excellent functional group compatibility. Furthermore, the addition of hydrochloric acid promotes the decomposition of copper complexes, which is beneficial for postprocessing.
据报道，使用二恶唑酮与喹啉氧化物通过铜（I）催化实现了2-乙酰氨基喹啉氧化物的高度区域选择性合成。该反应条件温和，官能团兼容性优异。此外，添加盐酸可促进铜配合物的分解，这有利于后处理。
