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肺泡蛋白沉积症:临床表现、诊断难点和治疗方法。

Pulmonary alveolar proteinosis: presentation, diagnostic challenges, and management.

机构信息

North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

出版信息

Br J Hosp Med (Lond). 2024 Sep 30;85(9):1-6. doi: 10.12968/hmed.2024.0250. Epub 2024 Sep 9.

Abstract

Pulmonary alveolar proteinosis is a rare diffuse lung disease; diagnosis and treatment of which is often delayed. We present the case study of a 43-year-old male with a six-month history of worsening breathlessness and non-productive cough referred for specialist respiratory input. Rapid investigations, including high-resolution computed tomography (HRCT) and bronchoalveolar lavage, confirmed the diagnosis of pulmonary alveolar proteinosis. Treatment with whole lung lavage significantly improved pulmonary function and quality of life. We discuss the diagnosis and management of this condition and highlight the importance of early recognition and multidisciplinary teamwork in managing pulmonary alveolar proteinosis.

摘要

肺泡蛋白沉积症是一种罕见的弥漫性肺部疾病,其诊断和治疗往往被延误。我们报告了一例 43 岁男性病例,该男性有六个月的进行性呼吸困难和干咳病史,被转介到专科进行呼吸治疗。快速的检查,包括高分辨率计算机断层扫描(HRCT)和支气管肺泡灌洗,证实了肺泡蛋白沉积症的诊断。全肺灌洗治疗显著改善了肺功能和生活质量。我们讨论了这种情况的诊断和管理,并强调了早期识别和多学科团队合作在管理肺泡蛋白沉积症中的重要性。

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