健康新生儿及高胆红素血症新生儿血清对大肠杆菌的杀菌活性。
The bactericidal activity of sera of healthy neonates and newborns with hyperbilirubinaemia to E. coli.
作者信息
Miler I, Vondrácek J, Hromádková L
出版信息
Czech Med. 1979;2(1-2):29-40.
PMID:393477
Abstract
Cord and newborn sera were found to possess a significantly decreased in vitro bactericidal activity to E. coli as compared to sera of adults. Hyperbilirubinaemia in neonataes suffering from both Rh and ABO incompatibility results in a further significant impairment of bactericidal activity of their sera in comparison to healthy newborn infants. Exchange transfusion considerably improved this serum antibacterial activity. The possible mechanism of toxic action of unconjugated bilirubin on the cells of the immune system is discussed.
摘要
与成人血清相比，发现脐带血和新生儿血清对大肠杆菌的体外杀菌活性显著降低。与健康新生儿相比，患有Rh和ABO血型不合的新生儿的高胆红素血症导致其血清杀菌活性进一步显著受损。换血疗法显著改善了这种血清抗菌活性。本文讨论了未结合胆红素对免疫系统细胞的毒性作用的可能机制。
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