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健康新生儿及高胆红素血症新生儿血清对大肠杆菌的杀菌活性。

The bactericidal activity of sera of healthy neonates and of newborns with hyperbilirubinaemia to Escherichia coli.

作者信息

Miler I, Vondrácek J, Hromádková L

出版信息

Folia Microbiol (Praha). 1979;24(2):143-52. doi: 10.1007/BF02927298.

DOI:10.1007/BF02927298
PMID:378780
Abstract

Cord and newborn sera were found to possess a significantly decreased in vitro bactericidal activity to Escherichia coli as compared to sera of adult individuals. Hyperbilirubinaemia in neonates suffering from both Rh and ABO incompatibility results in a further significant impairment of the bactericidal activity of their sera in comparison with healthy newborn infants. Exchange transfusion improved considerably the serum bactericidal activity. The possible mechanism of toxic action of unconjugated bilirubin on cells of the immune system is discussed.

摘要

与成人血清相比，发现脐带血和新生儿血清对大肠杆菌的体外杀菌活性显著降低。患有Rh和ABO血型不合的新生儿的高胆红素血症导致其血清杀菌活性与健康新生儿相比进一步显著受损。换血疗法显著改善了血清杀菌活性。本文讨论了未结合胆红素对免疫系统细胞毒性作用的可能机制。

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The bactericidal activity of sera of healthy neonates and of newborns with hyperbilirubinaemia to Escherichia coli.健康新生儿及高胆红素血症新生儿血清对大肠杆菌的杀菌活性。
Folia Microbiol (Praha). 1979;24(2):143-52. doi: 10.1007/BF02927298.
2
The bactericidal activity of sera of healthy neonates and newborns with hyperbilirubinaemia to E. coli.健康新生儿及高胆红素血症新生儿血清对大肠杆菌的杀菌活性。
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Serum response of Escherichia coli strains causing dyspepsia and urinary tract infection: relation to alpha-hemolysin production and O type.引起消化不良和尿路感染的大肠杆菌菌株的血清反应：与α-溶血素产生及O型的关系

本文引用的文献

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A STUDY OF THE RELATIONSHIP OF THE NORMAL BACTERICIDAL ACTIVITY OF HUMAN SERUM TO BACTERIAL INFECTION.人体血清正常杀菌活性与细菌感染关系的研究
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Bactericidal activity of normal serum against bacterial cultures. II. Activity against Eschericha coli strains.正常血清对细菌培养物的杀菌活性。II. 对大肠杆菌菌株的活性
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THE SELECTIVITY OF THE HUMAN PLACENTA IN THE TRANSFER OF PLASMA PROTEINS FROM MOTHER TO FETUS.
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Folia Microbiol (Praha). 1980;25(6):483-90. doi: 10.1007/BF02897214.
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Bilirubin inhibits the chemotactic activity of human polymorphonuclear leukocytes in vitro.胆红素在体外可抑制人多形核白细胞的趋化活性。
Folia Microbiol (Praha). 1981;26(5):413-6. doi: 10.1007/BF02927337.
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Bactericidal and bacteriolytic activity of serum against gram-negative bacteria.血清对革兰氏阴性菌的杀菌和溶菌活性。
Microbiol Rev. 1983 Mar;47(1):46-83. doi: 10.1128/mr.47.1.46-83.1983.
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The effect of bilirubin on the Fc receptor expression and phagocytic activity of mouse peritoneal macrophages.胆红素对小鼠腹腔巨噬细胞Fc受体表达及吞噬活性的影响。
Folia Microbiol (Praha). 1985;30(4):373-80. doi: 10.1007/BF02927593.
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The in vitro cytotoxic effect of bilirubin on human lymphocytes and granulocytes.胆红素对人淋巴细胞和粒细胞的体外细胞毒性作用。
Folia Microbiol (Praha). 1985;30(3):272-6. doi: 10.1007/BF02923520.
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The effect of bilirubin on the phagocytic activity of mouse peripheral granulocytes and monocytes in vivo.胆红素对小鼠外周粒细胞和单核细胞体内吞噬活性的影响。
Folia Microbiol (Praha). 1985;30(3):267-71.
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Cytotoxic activity in the coelomic fluid of the annelid Eisenia foetida Sav.
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人胎盘在血浆蛋白从母体向胎儿转移过程中的选择性
J Clin Invest. 1964 Oct;43(10):1938-51. doi: 10.1172/JCI105068.
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SERUM BACTERICIDAL ACTIVITY IN PATIENTS WITH PYELONEPHRITIS.肾盂肾炎患者的血清杀菌活性
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The complement-dependent bacteriolytic activity of normal human serum. I. The effect of pH and ionic strength and the role of lysozyme.正常人血清的补体依赖性溶菌活性。I. pH值和离子强度的影响以及溶菌酶的作用。
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Transient 19S gammaglobulin deficiency in the newborn infant, and its significance.新生儿短暂性19Sγ球蛋白缺乏及其意义。
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Antibacterial substances in placentas and serums of mothers and newborn infants.母亲和新生儿胎盘及血清中的抗菌物质。
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Serum complement in the newborn. An investigation of complement activity in normal infants and in Rh and AB hemolytic disease.新生儿的血清补体。对正常婴儿以及Rh和AB溶血病患儿补体活性的研究。
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Comparative levels of high molecular weight (19S) gamma globulin in maternal and umbilical cord sera.母体血清与脐带血清中高分子量（19S）γ球蛋白的比较水平。
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