Cowie R L, Langton M E, Escreet B C
S Afr Med J. 1985 Dec 7;68(12):878.
A group of patients with new or enlarging apical lung lesions thought to be tuberculous was randomly selected for observation without treatment. All were tuberculin-positive and all had sputum negative for Mycobacterium tuberculosis on direct examination and on culture. Of the 152 patients, 88 (58%) developed bacteriologically confirmed pulmonary tuberculosis during a follow-up period of up to 65 months.
一组被认为患有新发或增大的肺尖部结核样病变的患者被随机选取，进行未经治疗的观察。所有患者结核菌素试验均为阳性，且直接检查和培养的痰标本中结核分枝杆菌均为阴性。在152例患者中，88例（58%）在长达65个月的随访期内出现了细菌学确诊的肺结核。
