College of Veterinary Medicine and Biomedical Sciences, Department of Microbiology, Parasitology and Biotechnology, Chuo Kikuu, P. O. Box 3019, Morogoro, Tanzania.
Tanzania Livestock Research Institute (TALIRI), P.O. Box 834, Dodoma, Tanzania.
Trop Anim Health Prod. 2024 Sep 30;56(8):303. doi: 10.1007/s11250-024-04160-2.
The reported incidences of co-participation of Mycoplasma capricolum capripneumoniae (Mccp) and Pasteurella multocida in increased severity and pathogenesis of goats with Contagious caprine pleuropneumonia (CCPP) in sub-Saharan Africa elicited the study's purpose. Using the preferred reporting items for systematic review and meta-analysis (PRISMA) guideline, two search engines, namely Google Scholar and PubMed, were queried to systematically review all the available literature on the current epidemiological status of CCPP and Pneumonic Pasteurellosis co-concurrently detected in goats and assess the available treatment and control measures and their challenges in the Sub-Saharan region. The search was limited to papers published between 1998 and 2024, whereby only peer-reviewed English articles were included in the study. Review papers, papers displaying abstracts only, duplicated information, papers beyond the sub-Saharan Africa region and papers published in other languages were excluded from the study. Only articles with full text and focused on goats were included for further screening process and review. A total of 3311 articles were retrieved from both databases, whereas only 58 articles met the inclusion criteria and hence were included in the data analysis. Only eight countries namely, Ethiopia, Kenya, Uganda, Nigeria, Sudan, Eritrea, Zambia and Tanzania reported the occurrence of CCPP and or Pasteurellosis: Ethiopia 23/58(39%), Tanzania 18/58 (31%), 1/58(2%) Nigeria, 1/58(2%) Zambia, 1/58(2%) Eritrea, Uganda 2/58 (3%), 2/58(3%) Sudan and Kenya 10/58(16%). Only 5/58 (9%) reported the occurrence of pneumonic pasteurellosis in Nigeria and Ethiopia. Only Tanzania (75%) and Ethiopia (33%) reported Mccp and Pasteurella multocida co-isolation and/ or detection in CCPP cases. Information on the antimicrobial susceptibility profile of Mccp and Pasteurella multocida from Sub-Saharan Africa was unavailable. One vaccine against CCPP, namely F-38 inactivated, and one vaccine against pneumonic pasteurellosis were identified to be developed and used in Sub-Saharan Africa. Developing bivalent candidate vaccines for both etiological agents is highly recommended.
据报道，绵羊肺炎支原体（Mccp）和多杀性巴氏杆菌（Pasteurella multocida）在撒哈拉以南非洲的传染性山羊胸膜肺炎（CCPP）中共同参与疾病的严重程度和发病机制增加。本研究旨在利用系统评价和荟萃分析（PRISMA）的首选报告项目，通过两个搜索引擎，即 Google Scholar 和 PubMed，系统地回顾了所有关于 CCPP 目前流行病学状况的可用文献，以及同时在山羊中检测到的肺炎巴氏杆菌病，并评估了撒哈拉以南地区现有的治疗和控制措施及其挑战。搜索范围限于 1998 年至 2024 年期间发表的论文，仅纳入了该研究中的同行评议英文文章。综述论文、仅显示摘要的论文、重复信息的论文、超出撒哈拉以南非洲地区的论文以及用其他语言发表的论文均被排除在研究之外。只有全文且专注于山羊的论文才被纳入进一步筛选和审查过程。从这两个数据库中检索到了 3311 篇文章，其中只有 58 篇文章符合纳入标准，因此被纳入数据分析。只有 8 个国家，即埃塞俄比亚、肯尼亚、乌干达、尼日利亚、苏丹、厄立特里亚、赞比亚和坦桑尼亚报告了 CCPP 和/或巴氏杆菌病的发生：埃塞俄比亚 23/58（39%）、坦桑尼亚 18/58（31%）、尼日利亚 1/58（2%）、赞比亚 1/58（2%）、厄立特里亚 1/58（2%）、乌干达 2/58（3%）、苏丹 2/58（3%）和肯尼亚 10/58（16%）。只有 5/58（9%）篇报告在尼日利亚和埃塞俄比亚发生了肺炎巴氏杆菌病。只有坦桑尼亚（75%）和埃塞俄比亚（33%）报告了 Mccp 和多杀性巴氏杆菌在 CCPP 病例中的共同分离和/或检测。关于撒哈拉以南非洲 Mccp 和多杀性巴氏杆菌的抗菌药物敏感性谱的信息不可用。发现了一种针对 CCPP 的疫苗，即 F-38 灭活疫苗，以及一种针对肺炎巴氏杆菌病的疫苗，已在撒哈拉以南非洲开发和使用。强烈建议开发针对这两种病原体的双价候选疫苗。
