University of Alabama at Birmingham Marnix E. Heersink School of Medicine, Birmingham, AL, USA.
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Curr Atheroscler Rep. 2024 Nov;26(11):617-628. doi: 10.1007/s11883-024-01237-z. Epub 2024 Sep 30.
To provide a comprehensive overview of hypertriglyceridemia (HTG) in youth, identifying gaps in categorizing triglyceride (TG) levels and management strategies, and exploring new therapies for TG reduction.
Non-fasting TG levels as important cardiovascular (CV) risk indicators, with HTG's pathophysiology involving genetic and secondary factors affecting TG metabolism. Emerging treatments, including those affecting the lipoprotein lipase complex and inhibiting proteins like apoC3 and ANGPTL3, show promise. The review highlights the need for specific management approaches for youth, the significance of non-fasting TG levels, and the potential of new therapies in reducing CV and pancreatitis risks, advocating for further research on these treatments' efficacy and safety.
全面概述青少年高甘油三酯血症（HTG），确定在分类甘油三酯（TG）水平和管理策略方面的差距，并探讨降低 TG 的新疗法。
非空腹 TG 水平作为重要的心血管（CV）风险指标，HTG 的病理生理学涉及影响 TG 代谢的遗传和继发因素。新兴的治疗方法，包括影响脂蛋白脂肪酶复合物和抑制载脂蛋白 C3 和 ANGPTL3 等蛋白的方法，显示出前景。该综述强调了针对青少年的具体管理方法的必要性、非空腹 TG 水平的重要性以及新疗法在降低 CV 和胰腺炎风险方面的潜力，倡导对这些治疗方法的疗效和安全性进行进一步研究。
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