γδ T 细胞免疫表型在人类衰老研究中的应用。

γδ T-Cell Immunophenotype for the Study of Human Aging.

机构信息

Central Laboratory of Advanced Diagnosis and Biomedical Research, University Hospital "P. Giaccone", Palermo, Italy.

Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy.

出版信息

Methods Mol Biol. 2025;2857:45-59. doi: 10.1007/978-1-0716-4128-6_5.

DOI:10.1007/978-1-0716-4128-6_5

PMID:39348054

Abstract

Flow cytometry serves as a crucial tool in immunology, allowing for the detailed analysis of immune cell populations. γδ T cells, a subset of T cells, play pivotal roles in immune surveillance and immune aging. Assessing the phenotype and functional capabilities of γδ T cells isolated from whole blood or tissue within the context of human aging yields invaluable insights into the dynamic changes affecting immune function, tissue homeostasis, susceptibility to infections, and inflammatory responses.

摘要

流式细胞术在免疫学中是一种至关重要的工具，可以对免疫细胞群体进行详细分析。γδ T 细胞是 T 细胞的一个亚群，在免疫监视和免疫衰老中发挥着关键作用。评估从人类衰老时的全血或组织中分离出的γδ T 细胞的表型和功能能力，可以深入了解影响免疫功能、组织稳态、感染易感性和炎症反应的动态变化。