Al-Murshady Ahmed K, Al-Groosh Dheaa H
Department of Orthodontics, College of Dentistry, University of Baghdad, Bab Al-Muadham, 10047, Baghdad, Iraq.
Karbala Health Directorate, Ministry of Health, 56001, Karbala, Iraq.
Appl Biochem Biotechnol. 2025 Feb;197(2):1010-1024. doi: 10.1007/s12010-024-05062-7. Epub 2024 Sep 30.
This study aimed to evaluate the antimicrobial effect of coated orthodontic molar tubes (COMT) with zinc oxide nanoparticles (ZnO NPs) using an electrophoretic deposition method (EPD) and to evaluate the orthodontic molar tubes (OMT) bond failure rate. Seventy-two orthodontic molar tubes (OMTs) for second molars were divided into two groups 36 each; one group coated with ZnO NPs and the other control negative uncoated. The OMT was coated using the EPD method with ZnO NPs in a concentration of 10 g/l. The OMTs were randomly allocated using a split-mouth, cross-quadrant design. After 2 weeks of appliance placement, swabs were taken from the surface of the OMTs for microbial assessment against Streptococcus mutans, Lactobacillus acidophilus, and total bacterial counts; additionally, plaque and gingival indices were assessed. The patient was followed for 3 months to evaluate the bond failure rate. The COMT showed a statistically significant reduction in total bacterial accounts, S. mutans, and L. acidophilus compared to UOMT (P < 0.001). Furthermore, the plaque and gingival indices near COMT were significantly less than that of UOMT. The bond failure rate was not significant between the COMT and UOMT. The COMT with ZnO NPs has potent antibacterial activity against the tested pathogens with a reduction in the amount of plaque accumulation. The use of the EPD method was feasible without adverse effects on the orthodontic molar tubes bond failure rate.
本研究旨在评估采用电泳沉积法（EPD）制备的含氧化锌纳米颗粒（ZnO NPs）的正畸磨牙管（COMT）的抗菌效果，并评估正畸磨牙管（OMT）的粘结失败率。将72个第二磨牙用正畸磨牙管（OMT）分为两组，每组36个；一组涂覆ZnO NPs，另一组为未涂覆的对照阴性组。使用EPD法将浓度为10 g/l的ZnO NPs涂覆在OMT上。采用分口、跨象限设计对OMT进行随机分配。矫治器放置2周后，从OMT表面采集拭子，进行针对变形链球菌、嗜酸乳杆菌的微生物评估以及总细菌计数；此外，还评估了菌斑指数和牙龈指数。对患者随访3个月以评估粘结失败率。与未涂覆的正畸磨牙管（UOMT）相比，COMT的总细菌数、变形链球菌和嗜酸乳杆菌数量在统计学上有显著降低（P < 0.001）。此外，COMT附近的菌斑指数和牙龈指数明显低于UOMT。COMT和UOMT之间的粘结失败率无显著差异。含ZnO NPs的COMT对受试病原体具有强大的抗菌活性，且牙菌斑积聚量减少。使用EPD法是可行的，对正畸磨牙管的粘结失败率没有不利影响。
