Bass H, Trenchard P M, Mustow M J
Vox Sang. 1985;48(2):65-71. doi: 10.1111/j.1423-0410.1985.tb00149.x.
A microwave oven has been used to obtain rapid and controlled thawing of frozen plasma packs for cryoprecipitate production. The resulting factor VIII yields were higher than the average of 77.8 IU (in a volume of 17.2 ml) obtained by the slow overnight thaw procedures in routine use. Assays on 10 individual packs showed mean results of 142 +/- 24.5 IU factor VIII procoagulant activity, 188.6 +/- 51.68 IU factor VIII-related antigen, 0.152 +/- 0.05 g fibrinogen and 218.9 +/- 66.5 IU fibronectin in a volume of 23.2 +/- 6.6 ml. The results of this preliminary study indicate that microwave thawing of plasma is worthy of further investigation and should be reconsidered for routine production of cryoprecipitate and high yield fibronectin.
已使用微波炉对冷冻血浆袋进行快速且可控的解冻，以生产冷沉淀。由此获得的凝血因子 VIII 产量高于常规使用的缓慢过夜解冻程序所获得的平均产量 77.8 IU（体积为 17.2 ml）。对 10 个独立血浆袋的检测显示，在体积为 23.2 +/- 6.6 ml 的样本中，凝血因子 VIII 促凝活性平均结果为 142 +/- 24.5 IU，凝血因子 VIII 相关抗原为 188.6 +/- 51.68 IU，纤维蛋白原为 0.152 +/- 0.05 g，纤连蛋白为 218.9 +/- 66.5 IU。这项初步研究的结果表明，血浆的微波解冻值得进一步研究，并且在冷沉淀和高产纤连蛋白的常规生产中应重新考虑使用。
