Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Anticancer Res. 2024 Oct;44(10):4579-4584. doi: 10.21873/anticanres.17287.
BACKGROUND/AIM: The function of the S-100 protein family member hornerin (HRNR) in gastric cancer (GC) tissues is largely unknown. We researched the clinical significance of HRNR expression in GC tissues of patients with pathological (p)Stage II/III GC after curative resection.
We included patients with pStage II/III GC who underwent curative gastrectomy (n=253). Expression levels of HRNR in GC tissue and in the adjacent normal mucosa were determined using quantitative real-time polymerase chain reaction. Clinicopathological features and overall survival (OS) were compared in patients with different HRNR expression levels in GC tissue.
HRNR expression levels were significantly higher in GC tissues than in the adjacent normal mucosa. HRNR expression level in GC tissue showed sex differences. The 5-year OS rate in the high-HRNR expression group was significantly worse than that in the low-expression group (5-year survival 53.6% vs. 74.9%; p=0.004). Furthermore, on multivariate analysis, high-HRNR expression was an independent predictor of poor OS (hazard ratio=1.534; 95% confidence interval=1.130-2.618; p=0.011).
In patients with pStage II/III GC after curative gastrectomy, HRNR expression in GC tissue may be a useful prognostic marker.
背景/目的：S-100 蛋白家族成员 hornerin（HRNR）在胃癌（GC）组织中的功能很大程度上是未知的。我们研究了根治性切除术后病理（p）Ⅱ/Ⅲ期 GC 患者 GC 组织中 HRNR 表达的临床意义。
我们纳入了接受根治性胃切除术的 pⅡ/Ⅲ期 GC 患者（n=253）。使用实时定量聚合酶链反应测定 GC 组织和相邻正常黏膜中 HRNR 的表达水平。比较了 GC 组织中 HRNR 不同表达水平患者的临床病理特征和总生存期（OS）。
GC 组织中 HRNR 的表达水平明显高于相邻的正常黏膜。GC 组织中 HRNR 的表达水平存在性别差异。高 HRNR 表达组的 5 年 OS 率明显低于低表达组（5 年生存率 53.6% vs. 74.9%；p=0.004）。此外，多因素分析显示，高 HRNR 表达是 OS 不良的独立预测因素（危险比=1.534；95%置信区间=1.130-2.618；p=0.011）。
在接受根治性胃切除术后的 pⅡ/Ⅲ期 GC 患者中，GC 组织中 HRNR 的表达可能是一种有用的预后标志物。
