Adedeji M O
Acta Haematol. 1985;74(1):10-3. doi: 10.1159/000206155.
Patients with sickle cell disease have an increased tendency to develop frequent and severe pyogenic infections. Lymphocyte subpopulations were studied in 14 patients with homozygous sickle cell anaemia (SCA) using the OKT monoclonal antibody. The mean absolute lymphocyte counts observed in patients with SCA were similar to that of controls. The OKT8+ lymphocytes were significantly higher in SCA patients than in controls. The mean OKT3+ and OKT4+ lymphocytes were significantly lower in SCA patients than in controls, and there is a reversal of the normal OKT4+: OKT8+ ratio. The number of B cells present, as detected by surface membrane immunoglobulin, was significantly higher in SCA patients when compared with control values. These preliminary findings suggest an important mechanism to further explain the increased tendency to infection in SCA patients, in addition to the previously described immunological disorders and the asplenic state.
镰状细胞病患者发生频繁且严重的化脓性感染的倾向增加。使用OKT单克隆抗体对14例纯合子镰状细胞贫血（SCA）患者的淋巴细胞亚群进行了研究。SCA患者观察到的平均绝对淋巴细胞计数与对照组相似。SCA患者的OKT8 +淋巴细胞显著高于对照组。SCA患者的平均OKT3 +和OKT4 +淋巴细胞显著低于对照组，且正常的OKT4 +：OKT8 +比值发生了逆转。通过表面膜免疫球蛋白检测到的SCA患者B细胞数量与对照值相比显著更高。这些初步发现提示了一个重要机制，除了先前描述的免疫紊乱和无脾状态外，可进一步解释SCA患者感染倾向增加的原因。
