Ballester O F, Abdallah J M, Prasad A S
Am J Hematol. 1986 Jan;21(1):23-7. doi: 10.1002/ajh.2830210104.
In this study, we evaluated lymphocyte subpopulations in 23 adults with SCA. When compared to controls, SCA patients had higher lymphocyte counts with normal numbers of T101+ cells (T-lymphocytes) and T4+ cells. T8+ cells were significantly increased in SCA patients in comparison to controls (1684 +/- 243 vs 980 +/- 367, p less than .001). This increment was largely dependent on a T101-, T8+ cell population. The SCA patients as a group had significantly decreased T4/T8 ratio (p less than .0001). The SCA patients with history of blood transfusions had higher T4+ cells numbers and higher T4/T8 ratio, but no other significant differences from nontransfused patients were noted. Our results are different from those reported for nontransfused children with SCA who showed normal T4/T8 ratio. Thus, a distinct pattern of abnormalities is seen in the lymphocyte subpopulations of adult SCA patients, unrelated to their exposure to blood transfusions.
在本研究中，我们评估了23例成年镰状细胞贫血（SCA）患者的淋巴细胞亚群。与对照组相比，SCA患者淋巴细胞计数较高，T101 +细胞（T淋巴细胞）和T4 +细胞数量正常。与对照组相比，SCA患者的T8 +细胞显著增加（1684±243对980±367，p＜0.001）。这种增加主要取决于T101 -、T8 +细胞群。SCA患者作为一个群体，其T4/T8比值显著降低（p＜0.0001）。有输血史的SCA患者T4 +细胞数量较多，T4/T8比值较高，但与未输血患者相比，未发现其他显著差异。我们的结果与报道的未输血的儿童SCA患者不同，后者T4/T8比值正常。因此，在成年SCA患者的淋巴细胞亚群中可见一种独特的异常模式，与他们是否接触过输血无关。
