Ording H, Hald A, Sjøntoft E
Acta Anaesthesiol Scand. 1985 Oct;29(7):698-701. doi: 10.1111/j.1399-6576.1985.tb02283.x.
Three malignant hyperthermia susceptible (MHS) and three normal Danish landrace pigs were heated using a water-heated mattress, warm blankets and warm intravenous saline during anaesthesia with barbiturate and 50% nitrous oxide in oxygen. The MHS pigs developed typical malignant hyperthermia (MH) at a rectal temperature of 41.0 +/- 0.7 degrees C, whereas the normal pigs tolerated heating to the same temperature without any ill effects. Haemodynamic and metabolic findings during MH were similar to those previously reported for anaesthetic-induced MH in pigs. Heat intolerance may thus be one factor in the genesis of MH.
