依他诺龙（5-β-孕烷醇酮）不会引发恶性高热易感猪的恶性高热，并且会减弱氟烷引发的恶性高热。

Eltanolone (5-beta-pregnanolone) does not trigger, and attenuates halothane triggering of, malignant hyperthermia in malignant hyperthermia susceptible swine.

作者信息

Harrison G G, Dyer R A, Llewellyn R L, James M F

机构信息

Department of Anaesthesia, University of Cape Town and Groote Schuur Hospital, Anzio Road, Observatory, Cape Town, 7925, South Africa.

出版信息

Pharmacol Res. 1999 Feb;39(2):103-6. doi: 10.1006/phrs.1998.0415.

DOI:10.1006/phrs.1998.0415

PMID:10072700

Abstract

Eltanolone is the lipid emulsion formulation, for intravenous use, of the steroid anaesthetic 5-beta-pregnanolone. We have screened this agent in malignant hyperthermia susceptible (MHS) Landrace swine to assess its potential to trigger the Malignant Hyperthermia (MH) syndrome in MHS subjects or to influence halothane triggering of MH in such patients. Administered in anaesthetic concentration, eltanolone did not trigger the MH syndrome in MHS swine. When co-administered in low dosage with halothane, the drug prevented initiation of the MH syndrome in four of eight pigs and attenuated its progress in the remainder.

摘要

艾他诺龙是类固醇麻醉剂5-β-孕烷醇酮的脂质乳剂配方，供静脉使用。我们已在易患恶性高热（MHS）的长白猪中筛选了该药物，以评估其在MHS个体中引发恶性高热（MH）综合征的可能性，或影响此类患者中氟烷引发MH的情况。以麻醉浓度给药时，艾他诺龙不会在MHS猪中引发MH综合征。当与氟烷低剂量共同给药时，该药物在八头猪中的四头中预防了MH综合征的发作，并减轻了其余猪中该综合征的进展。