Crawford Alexander M, Striano Brendan M, Bryan Matthew R, Amakiri Ikechukwu C, Williams Donnell L, Nguyen Andrew T, Hatton Malina O, Simpson Andrew K, Schoenfeld Andrew J
Harvard Combined Orthopaedic Residency Program, Harvard Medical School, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
Spine J. 2025 Feb;25(2):237-243. doi: 10.1016/j.spinee.2024.09.030. Epub 2024 Sep 28.
Expandable transforaminal lumbar interbody fusion (TLIF) cages have become popular in recent years due to anticipated advantages of increased disc height, improved segmental lordosis, and ease of implantation. Such benefits have not been conclusively demonstrated in the literature.
To determine whether expandable cages increase disc height and segmental lordosis in a durable way following surgery and compare complication profiles between cage types.
STUDY DESIGN/SETTING: Retrospective cohort study conducted within a large academic health system involving 31 different spine surgeons.
Adults undergoing single-level TLIF for an indication other than infection, tumor, trauma, or revision instrumentation from 2021 to 2023.
Our primary outcomes were changes in segmental disc height, segmental lordosis, and L4-S1 lordosis at 2 weeks, 6 months, and 1 year following surgery relative to baseline. Our secondary outcomes were frequencies of incidental durotomies, surgical site infections, readmissions, death, subsidence, and unplanned return to the operating room.
Radiographic variables were collected from our institutional imaging registry. Demographics and surgical characteristics were abstracted from chart review. Generalized linear modeling was used for each primary outcome, with cage type (expandable vs static) as our primary predictor and age, biologic sex, race, CCI, year of surgery, duration of surgery, invasiveness of surgery, surgeon specialty (Orthopedics vs Neurosurgery), and level of surgery as covariates.
Our cohort consisted of 417 patients with a mean age of 62. Static cages were used in 306 patients and expandable cages in 111. Expandable cages were associated with increased changes in disc height relative to static cages at 2 weeks (1.1 mm [0.2-1.9]; p=.01) and 6 months (1.2 mm [0.2-2.3]; p=.02) following surgery, but differences were no longer significant at 1 year (0.4 mm [-0.9-1.8]; p=.4). Expandable cages were found to subside more commonly than static cages (14.1% vs 6.6%; p=.04). No significant differences between cage types were identified in lordotic parameters at any timepoint (p=0.25 to p=0.97).
Expandable cages were associated with an initial increase in disc height relative to static cages, but this difference diminished with the first year of surgery, likely due to a higher rate of subsidence within the expandable cohort.
近年来,可扩张经椎间孔腰椎椎间融合(TLIF)椎间融合器因预期能增加椎间盘高度、改善节段性前凸及便于植入等优势而受到欢迎。但这些益处尚未在文献中得到确凿证实。
确定可扩张椎间融合器在术后能否持久增加椎间盘高度和节段性前凸,并比较不同类型椎间融合器的并发症情况。
研究设计/地点:在一个大型学术医疗系统内进行的回顾性队列研究,涉及31位不同的脊柱外科医生。
2021年至2023年因非感染、肿瘤、创伤或翻修器械等适应证接受单节段TLIF手术的成年人。
我们的主要观察指标是术后2周、6个月和1年时相对于基线的节段性椎间盘高度、节段性前凸和L4-S1前凸的变化。次要观察指标是意外硬脊膜切开、手术部位感染、再入院、死亡、下沉和计划外重返手术室的发生率。
从我们机构的影像登记系统中收集影像学变量。从病历回顾中提取人口统计学和手术特征。对每个主要观察指标使用广义线性模型,将椎间融合器类型(可扩张型与静态型)作为主要预测因素,将年龄、生物性别、种族、CCI、手术年份、手术时长、手术侵入性、外科医生专业(骨科与神经外科)和手术节段作为协变量。
我们的队列包括417例患者,平均年龄62岁。306例患者使用静态椎间融合器,111例使用可扩张椎间融合器。与静态椎间融合器相比,可扩张椎间融合器在术后2周(1.1毫米[0.2 - 1.9];p = 0.01)和6个月(1.2毫米[0.2 - 2.3];p = 0.02)时与椎间盘高度变化增加相关,但在1年时差异不再显著(0.4毫米[-0.9 - 1.8];p = 0.4)。发现可扩张椎间融合器比静态椎间融合器更常出现下沉(14.1%对6.6%;p = 0.04)。在任何时间点,两种类型椎间融合器在前凸参数上均未发现显著差异(p = 0.25至p = 0.97)。
相对于静态椎间融合器,可扩张椎间融合器与术后初期椎间盘高度增加相关,但这种差异在手术第一年时减小,可能是由于可扩张椎间融合器组下沉率较高。