Liu Ying, Ai Hao
Department of Gynaecology and Obstetrics, The Third Affiliated Hospital of Jinzhou Medical University; Liaoning Provincial Key Laboratory of Follicular Development and Reproductive Health, Jinzhou Medical University, No. 2, Section 5, Heping Road, Linghe District, Jinzhou City, Liaoning Province, 121000, P.R. China.
Department of Gynaecology and Obstetrics, The Third Affiliated Hospital of Jinzhou Medical University; Liaoning Provincial Key Laboratory of Follicular Development and Reproductive Health, Jinzhou Medical University, No. 2, Section 5, Heping Road, Linghe District, Jinzhou City, Liaoning Province, 121000, P.R. China.
Biochim Biophys Acta Rev Cancer. 2024 Nov;1879(6):189192. doi: 10.1016/j.bbcan.2024.189192. Epub 2024 Sep 29.
This article provides an in-depth review of the Human Papillomavirus (HPV), a predominant etiological factor in cervical cancer, exploring its pathophysiology, epidemiology, and mechanisms of oncogenesis. We examine the role of proteins, DNA methylation markers, and non-coding RNAs as predictive biomarkers in cervical cancer, highlighting their potential in refining diagnostic and prognostic practices. The evolution and efficacy of cervical cancer screening methods, including the Papanicolaou smear, HPV testing, cytology and HPV test, and colposcopy techniques, are critically analyzed. Furthermore, the article delves into the current landscape and future prospects of prophylactic HPV vaccines and therapeutic vaccines, underscoring their significance in the prevention and potential treatment of HPV-related diseases. This comprehensive review aims to synthesize recent advances and ongoing challenges in the field, providing a foundation for future research and clinical strategies in the prevention and management of cervical cancer.
本文对人乳头瘤病毒（HPV）进行了深入综述，HPV是宫颈癌的主要病因，探讨了其病理生理学、流行病学和致癌机制。我们研究了蛋白质、DNA甲基化标志物和非编码RNA作为宫颈癌预测生物标志物的作用，强调了它们在完善诊断和预后实践方面的潜力。对宫颈癌筛查方法的演变和效果进行了批判性分析，包括巴氏涂片、HPV检测、细胞学和HPV检测以及阴道镜检查技术。此外，本文还深入探讨了预防性HPV疫苗和治疗性疫苗的现状和未来前景，强调了它们在预防和潜在治疗HPV相关疾病方面的重要性。这一全面综述旨在综合该领域的最新进展和持续挑战，为未来预防和管理宫颈癌的研究及临床策略奠定基础。
