Department of Medical Administ, Chongqing Public Health Medical Center, Chongqing, China.
Department of the Tuberculosis, Chongqing Public Health Medical Center, Chongqing, China.
BMC Public Health. 2024 Nov 1;24(1):3031. doi: 10.1186/s12889-024-20490-0.
Diet may influence susceptibility of human papillomavirus (HPV) infection by affecting inflammation and immunity. However, the association between HPV infection and the inflammatory potential of diet has not been investigated. The research aimed to examine the correlation between HPV status and the dietary inflammatory index (DII).
We utilized data from the National Health and Nutrition Examination Survey (NHANES) 2003-2016 to investigate the correlation between DII and HPV status among 9,256 women aged 18-59 years. DII scores were calculated based on 24-hour dietary recall interviews. The association between HPV status and DII was analyzed using weighted logistic regression and restricted cubic spline (RCS).
Women with HPV infection exhibited higher DII scores than those without HPV infection. An increased likelihood of HPV infection was found to be significantly associated with higher DII scores (OR = 1.05, 95% CI: 1.01-1.09, P = 0.021), after full multivariate adjustment. Compared with the lowest tertile of DII scores, the ORs (95% CIs) for HPV infection were 1.20 (1.01, 1.42) and 1.27 (1.07, 1.51) for the second and third tertiles, respectively (P for trend = 0.006). RCS analysis showed a U-shaped relationship between DII and HPV infection, with a breakpoint identified at 0.13.
Our findings suggest that a pro-inflammatory diet is associated with an increased likelihood of HPV infection among women in the United States. Dietary interventions to reduce inflammation may help prevent HPV infection and related diseases.
饮食可能通过影响炎症和免疫来影响人类乳头瘤病毒（HPV）感染的易感性。然而，HPV 感染与饮食炎症潜能之间的关联尚未得到研究。本研究旨在检验 HPV 状态与饮食炎症指数（DII）之间的相关性。
我们利用了 2003-2016 年国家健康和营养调查（NHANES）的数据，调查了 9256 名 18-59 岁女性中 DII 与 HPV 状态之间的相关性。根据 24 小时膳食回顾访谈计算 DII 评分。使用加权逻辑回归和限制性三次样条（RCS）分析 HPV 状态与 DII 之间的关联。
HPV 感染的女性 DII 评分高于未感染 HPV 的女性。经过全多变量调整后，发现 HPV 感染的可能性增加与 DII 评分升高显著相关（OR=1.05，95%CI：1.01-1.09，P=0.021）。与 DII 评分最低三分位相比，DII 评分第二和第三三分位的 HPV 感染比值比（95%CI）分别为 1.20（1.01，1.42）和 1.27（1.07，1.51）（趋势 P=0.006）。RCS 分析显示 DII 与 HPV 感染之间呈 U 型关系，在 0.13 处存在一个转折点。
我们的研究结果表明，促炎饮食与美国女性 HPV 感染的可能性增加相关。减少炎症的饮食干预可能有助于预防 HPV 感染和相关疾病。
