小胶质细胞在中枢神经系统发育和可塑性中的作用。
Role of Microglia in Central Nervous System Development and Plasticity.
作者信息
Schafer Dorothy P, Stevens Beth, Bennett Mariko L, Bennett Frederick C
机构信息
Department of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, USA.
Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA; Howard Hughes Medical Institute, New York, New York 10032, USA
出版信息
Cold Spring Harb Perspect Biol. 2024 Sep 30. doi: 10.1101/cshperspect.a041810.
The nervous system comprises a remarkably diverse and complex network of cell types, which must communicate with one another with speed, reliability, and precision. Thus, the developmental patterning and maintenance of these cell populations and their connections with one another pose a rather formidable task. Emerging data implicate microglia, the resident myeloid-derived cells of the central nervous system (CNS), in spatial patterning and synaptic wiring throughout the healthy, developing, and adult CNS. Importantly, new tools to specifically manipulate microglia function have revealed that these cellular functions translate, on a systems level, to effects on overall behavior. In this review, we give a historical perspective of work to identify microglia function in the healthy CNS, and highlight exciting new discoveries about their contributions to CNS development, maintenance, and plasticity.
神经系统由一个极其多样和复杂的细胞类型网络组成，这些细胞必须以速度、可靠性和精确性相互通信。因此，这些细胞群体的发育模式形成和维持以及它们之间的连接构成了一项相当艰巨的任务。新出现的数据表明，小胶质细胞作为中枢神经系统（CNS）中驻留的髓系来源细胞，在整个健康、发育中和成年CNS的空间模式形成和突触连接中发挥作用。重要的是，专门操纵小胶质细胞功能的新工具表明，这些细胞功能在系统水平上转化为对整体行为的影响。在这篇综述中，我们给出了在健康CNS中鉴定小胶质细胞功能的工作的历史视角，并强调了关于它们对CNS发育、维持和可塑性贡献的令人兴奋的新发现。
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