首发精神分裂症患者单个外泌体表面蛋白表达特征分析：一项初步研究。
Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study.
作者信息
Zhang Sijie, Liao Aijun, Wang Yujue, Liu Qian, Ouyang Lijun, Peng Huiqing, Yuan Liu, Zhao Linlin, Yang Xinbo, Chen Xiaogang, He Ying, Li Zongchang
机构信息
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
China National Technology Institute on Mental Disorders & Hunan Key, Laboratory of Psychiatry and Mental Health, Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
出版信息
Schizophrenia (Heidelb). 2024 Sep 30;10(1):84. doi: 10.1038/s41537-024-00510-z.
Proximity barcoding assay, a high-throughput method for single-exosome analysis, was employed to profile surface proteins on individual exosomes of SCZ patients. This analysis identified five differentially expressed proteins (DEPs) between SCZ patients and healthy controls (HC) and six DEPs between antipsychotic responders and non-responders. Furthermore, two exosome clusters were found to be associated with SCZ, and certain DEPs were correlated with cognitive functions.
邻近条形码分析是一种用于单外泌体分析的高通量方法，被用于分析精神分裂症（SCZ）患者个体外泌体上的表面蛋白。该分析确定了SCZ患者与健康对照（HC）之间有5种差异表达蛋白（DEP），以及抗精神病药物应答者与无应答者之间有6种DEP。此外，发现两个外泌体簇与SCZ相关，且某些DEP与认知功能相关。
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