Department of Biomedical Science & Engineering, Dankook University, Cheonan, South Korea.
Exp Mol Med. 2024 Oct;56(10):2099-2104. doi: 10.1038/s12276-024-01311-1. Epub 2024 Oct 1.
Erythropoiesis, the process underlying the production of red blood cells, which are essential for oxygen transport, involves the development of hematopoietic stem cells into mature red blood cells. This review focuses on the critical roles of transcription factors and epigenetic mechanisms in modulating gene expression critical for erythroid differentiation. It emphasizes the significance of chromatin remodeling in ensuring gene accessibility, a key factor for the orderly progression of erythropoiesis. This review also discusses how dysregulation of these processes can lead to erythroid disorders and examines the promise of genome editing and gene therapy as innovative therapeutic approaches. By shedding light on the genomic regulation of erythropoiesis, this review suggests avenues for novel treatments for hematological conditions, underscoring the need for continued molecular studies to improve human health.
红细胞生成，即产生红细胞的过程，对于氧气运输至关重要，涉及造血干细胞向成熟红细胞的发展。本综述重点介绍了转录因子和表观遗传机制在调节红细胞分化关键基因表达中的关键作用。它强调了染色质重塑在确保基因可及性方面的重要性，基因可及性是红细胞生成有序进行的关键因素。本综述还讨论了这些过程的失调如何导致红细胞紊乱，并研究了基因组编辑和基因治疗作为创新治疗方法的前景。通过揭示红细胞生成的基因组调控，本综述为血液疾病的新治疗方法提供了途径，强调了继续进行分子研究以改善人类健康的必要性。
