Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand; Department of Endocrinology, Auckland District Health Board, Auckland, New Zealand.
Endocrinol Metab Clin North Am. 2017 Dec;46(4):935-945. doi: 10.1016/j.ecl.2017.07.005. Epub 2017 Sep 29.
One hundred years ago, vitamin D was identified as the cause and cure of osteomalacia. This role remains firmly established. Vitamin D influences skeletal mineralization principally through the regulation of intestinal calcium absorption. It has been proposed that vitamin D has direct beneficial effects on bone (besides the prevention of osteomalacia), but these have been difficult to establish in clinical trials. Meta-analyses of vitamin D trials show no effects on bone density or fracture risk when the baseline 25-hydroxyvitamin D is >40 nmol/L. A daily dose of 400 to 800 IU vitamin D is usually adequate to correct such deficiency.
一百年前，人们发现维生素 D 是导致和治疗佝偻病的原因。这一作用至今仍然明确。维生素 D 通过调节肠道钙吸收对骨骼矿化起主要作用。人们认为维生素 D 对骨骼有直接的有益作用（除了预防佝偻病之外），但这些作用在临床试验中很难确定。对维生素 D 试验的荟萃分析显示，当基线 25-羟维生素 D 水平>40nmol/L 时，维生素 D 对骨密度或骨折风险没有影响。每天摄入 400 至 800IU 维生素 D 通常足以纠正这种缺乏。
