Ocariza Moizle Grace Castro, Paton Louise Nancy, Templeton Evelyn Mary, Pemberton Christopher Joseph, Pilbrow Anna Pauline, Appleby Sarah
Department of Medicine, Christchurch Heart Institute, University of Otago (Christchurch), Christchurch, New Zealand.
J Cardiovasc Transl Res. 2025 Feb;18(1):48-57. doi: 10.1007/s12265-024-10560-4. Epub 2024 Sep 30.
The heart requires a substantial amount of energy to function, utilising various substrates including lipids, glucose and lactate as energy sources. In times of increased stress, lactate becomes the primary energy source of the heart, but persistently elevated lactate levels are linked to poor patient outcomes and increased mortality. Recently, carnosine dipeptidase II (CNDP2) was discovered to catalyse the formation of Lac-Phe, an exercise-induced metabolite derived from lactate, which has been shown to suppress appetite in mice and reduce adipose tissue in humans. This review discusses CNDP2, including its role in lactate clearance, carnosine hydrolysis, oxidative stress regulation, and involvement in metabolite regulation. The association between CNDP2 and cardiometabolic and renal diseases is also explored, and knowledge gaps are highlighted. CNDP2 appears to be a complex participant in human physiological processes and disease, necessitating additional research to unveil its functions and potential therapeutic applications.
心脏需要大量能量来维持功能，它利用包括脂质、葡萄糖和乳酸等多种底物作为能量来源。在压力增加时，乳酸成为心脏的主要能量来源，但乳酸水平持续升高与患者预后不良和死亡率增加有关。最近，发现肌肽二肽酶II（CNDP2）可催化Lac-Phe的形成，Lac-Phe是一种由乳酸衍生的运动诱导代谢产物，已被证明可抑制小鼠食欲并减少人体脂肪组织。本文综述了CNDP2，包括其在乳酸清除、肌肽水解、氧化应激调节以及代谢物调节中的作用。还探讨了CNDP2与心脏代谢和肾脏疾病之间的关联，并突出了知识空白。CNDP2似乎是人类生理过程和疾病中的一个复杂参与者，需要更多研究来揭示其功能和潜在的治疗应用。
