Ha Edra K, Shriner Daniel, Callier Shawneequa L, Riley Lorinda, Adeyemo Adebowale A, Rotimi Charles N, Bentley Amy R
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
University of Hawai'i at Mānoa, Honolulu, HI, USA.
NPJ Genom Med. 2024 Sep 30;9(1):45. doi: 10.1038/s41525-024-00428-6.
The role of genomic research and medicine in improving health continues to grow significantly, highlighting the need for increased equitable inclusion of diverse populations in genomics. Native Hawaiian and Pacific Islander (NHPI) communities are often missing from these efforts to ensure that the benefits of genomics are accessible to all individuals. In this article, we analyze the qualities of NHPI populations relevant to their inclusion in genomic research and investigate their current representation using data from the genome-wide association studies (GWAS) catalog. A discussion of the barriers NHPI experience regarding participating in research and recommendations to improve NHPI representation in genomic research are also included.
基因组研究和医学在改善健康方面的作用持续显著增强，这凸显了在基因组学中更公平地纳入不同人群的必要性。在确保所有人都能享受到基因组学益处的这些努力中，夏威夷原住民和太平洋岛民（NHPI）社区常常被遗漏。在本文中，我们分析了与NHPI人群纳入基因组研究相关的特质，并利用全基因组关联研究（GWAS）目录中的数据调查了他们目前的代表性情况。文中还讨论了NHPI人群在参与研究方面所面临的障碍以及提高NHPI人群在基因组研究中代表性的建议。
