Central Labs, King Khalid University, AlQura'a, Abha, Saudi Arabia.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Cell Biochem Funct. 2024 Dec;42(8):e70013. doi: 10.1002/cbf.70013.
Hepatocellular carcinoma (HCC) continues to pose a global health concern, necessitating the exploration of innovative therapeutic approaches. In the recent decade, targeting tumor stroma consisting of extracellular matrix (ECM), immune cells, vascular system, hypoxia, and also suppressive mechanisms in HCC has attracted interest in repressing tumor growth and metastasis. Phytochemicals have attained considerable attention because of their manifold biological effects and high capacity for anticancer activities. These chemical agents have shown the capability to modulate different cells and secretions within the stroma of malignancies. In recent years, the development of nanoformulations has further enhanced the therapeutic potential of phytochemicals by improving their solubility, bioavailability, and targeted delivery to tumor tissues. This review aims to provide an encyclopedic overview of the potential of phytochemicals and their nanoformulations as promising therapeutic strategies for targeting HCC. The review initially highlights the broad array of phytochemicals exhibiting potent anticancer properties, including flavonoids, alkaloids, terpenoids, and phenolic compounds, among others. Then, the nanoformulations and modification of these agents will be reviewed. Finally, we will review the latest experiments that have examined the modulation of HCC using adjuvant phytochemicals and their nanoformulations.
肝细胞癌（HCC）仍然是一个全球性的健康问题，需要探索创新的治疗方法。在过去的十年中，靶向由细胞外基质（ECM）、免疫细胞、血管系统、缺氧以及 HCC 中的抑制机制组成的肿瘤基质，以抑制肿瘤生长和转移，引起了人们的兴趣。植物化学物质因其多种生物学效应和高抗癌活性而受到广泛关注。这些化学物质已被证明能够调节恶性肿瘤基质中的不同细胞和分泌。近年来，纳米制剂的发展通过提高植物化学物质的溶解度、生物利用度和靶向肿瘤组织的递送，进一步提高了其治疗潜力。
本综述旨在全面概述植物化学物质及其纳米制剂作为治疗 HCC 的有前途的治疗策略的潜力。综述首先强调了具有强大抗癌特性的广泛的植物化学物质，包括类黄酮、生物碱、萜类化合物和酚类化合物等。然后，将回顾这些药物的纳米制剂和修饰。最后，我们将回顾最近使用辅助植物化学物质及其纳米制剂来调节 HCC 的实验。
