Alsharafi Mohammed, Zeren Yusuf, Ahmed Haifa, Alameri Abdu
Department of Mathematics, Faculty of Arts and Science, Yildiz Technical University, Esenler, Istanbul, 34220, Istanbul, Turkey.
Department of Mathematics, Faculty of Education, Art and Science, Aden University, Aden, Yemen.
Pharm Nanotechnol. 2024 Sep 27. doi: 10.2174/0122117385307798240830072353.
Various dendrimer nanoparticles have properties like multivalency, controlled size, and surface functionality that make them promising nanocarriers for targeted drug delivery and other applications in pharmaceutical sciences. The precise tunability of dendrimers is an advantage over other nanoparticles. The topological descriptors can be used to predict the physicochemical properties of dendrimers and optimize their branching pattern for specific applications. The second hyper-Zagreb index and co-index are computed for various chemical structures, including dendrimers, to facilitate the correlation between their structure and biological activity.
In this study, the second Hyper-Zagreb index and second Hyper-Zagreb polynomials were calculated for various chemical structures, such as the molecular graph of poly(propyl) ether imine dendrimer PETIM, nanostar dendrimer (D[p]), polypropylenimine octaamine dendrimer (NS[p]) and (NS[p]), polymer dendrimer (NS[p]) and NS[p]), fullerene dendrimer (NS[p]), and other classes of dendrimers.
By computing formulae and analyzing data and figures, we obtained new insights into the features of structure-property connections for these types of compounds of nanostar dendrimers.
The results can be used to optimize the properties of dendrimers for specific applications.
各种树枝状聚合物纳米颗粒具有多价性、可控尺寸和表面功能性等特性，使其成为用于靶向药物递送及制药科学中其他应用的有前景的纳米载体。树枝状聚合物的精确可调性是其相对于其他纳米颗粒的一个优势。拓扑描述符可用于预测树枝状聚合物的物理化学性质，并针对特定应用优化其分支模式。计算了包括树枝状聚合物在内的各种化学结构的第二超 Zagreb 指数和共指数，以促进其结构与生物活性之间的相关性。
在本研究中，计算了各种化学结构的第二超 Zagreb 指数和第二超 Zagreb 多项式，如聚（丙基）醚亚胺树枝状聚合物 PETIM、纳米星树枝状聚合物（D[p]）、聚丙基亚胺八胺树枝状聚合物（NS[p]）和（NS[p]）、聚合物树枝状聚合物（NS[p]）和 NS[p]）、富勒烯树枝状聚合物（NS[p]）以及其他类别的树枝状聚合物的分子图。
通过计算公式并分析数据和图表，我们对这些类型的纳米星树枝状聚合物化合物的结构 - 性质联系特征有了新的认识。
这些结果可用于优化树枝状聚合物在特定应用中的性质。
