Chen Yan-Jun, Xie Ming-Rong, Zhou Sheng-Qiang, Liu Fang
Graduate School of Hunan University of Chinese Medicine, Changsha, China.
National TCM Master Liu Zuyi Inheritance Studio, The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, China.
Front Neurol. 2024 Sep 16;15:1413762. doi: 10.3389/fneur.2024.1413762. eCollection 2024.
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder primarily affecting the elderly. Relevant studies suggest a significant connection between the mitochondria and PD. Publications exploring this connection have steadily increased in recent years. This study employs a bibliometric approach to comprehensively analyze the current status and future directions of the research on mitochondria and PD.
We retrieved data from the Web of Science database and used CiteSpace, VOSviewer, and "Bibliometrix" software to visually analyze various aspects of the research field. These aspects included the number of published papers, contributing countries and institutions, authors, publishing journals, cited references, and keywords.
Our analysis identified a total of 3,291 publications involving 14,670 authors from 2,836 organizations across 78 countries. The publication volume exhibited a continuous upward trend from 1999 to 2023. The United States emerged as the leading force in this research area, contributing the highest number of high-quality publications. Notably, the United States collaborated extensively with Germany and the United Kingdom. The University of Pittsburgh stood out as the most prolific institution. Harvard University had the highest academic influence and closely cooperated with the University of Pittsburgh, Juntendo University, and McGill University. Dr. Hattori Nobutaka was identified as the most prolific author, while Dr. Youle, Richard J emerged as the most influential author based on the highest average citation frequency. The was the most published journal. The most co-cited paper was titled "" The major keywords included oxidative stress, alpha-synuclein, pink1, mitophagy, and mitochondrial dysfunction. Mitofusin 2, ubiquitin, and mitochondrial quality control have been identified as new research hotspots in recent years.
Mitochondria-PD research is experiencing a steady increase in activity, fueled by increasing close collaboration between countries and different institutions. However, there is a need to further strengthen collaboration and communication between developed and developing nations. Current research has focused on the specific mechanisms of mitochondrial dysfunction and their relationship with PD. Mitofusin 2, ubiquitin, and mitochondrial quality control are positioned to be the hotspots and future research directions.
帕金森病（PD）是一种主要影响老年人的慢性进行性神经退行性疾病。相关研究表明线粒体与帕金森病之间存在显著联系。近年来，探索这种联系的出版物稳步增加。本研究采用文献计量学方法全面分析线粒体与帕金森病研究的现状和未来方向。
我们从Web of Science数据库检索数据，并使用CiteSpace、VOSviewer和“Bibliometrix”软件对该研究领域的各个方面进行可视化分析。这些方面包括发表论文的数量、贡献国家和机构、作者、发表期刊、被引参考文献和关键词。
我们的分析共确定了3291篇出版物，涉及来自78个国家2836个组织的14670名作者。从1999年到2023年，出版物数量呈持续上升趋势。美国是该研究领域的主导力量，贡献了最多的高质量出版物。值得注意的是，美国与德国和英国广泛合作。匹兹堡大学是最多产的机构。哈佛大学具有最高的学术影响力，并与匹兹堡大学、顺天堂大学和麦吉尔大学密切合作。Hattori Nobutaka博士被确定为最多产的作者，而Youle, Richard J博士基于最高的平均被引频次被确定为最具影响力的作者。 是发表最多的期刊。被共同引用最多的论文标题为“ ”。主要关键词包括氧化应激、α-突触核蛋白、pink1、线粒体自噬和线粒体功能障碍。线粒体融合蛋白2、泛素和线粒体质量控制已被确定为近年来新的研究热点。
线粒体 - 帕金森病研究活动正稳步增加，这得益于各国和不同机构之间日益密切的合作。然而，有必要进一步加强发达国家和发展中国家之间的合作与交流。当前的研究集中在线粒体功能障碍的具体机制及其与帕金森病的关系。线粒体融合蛋白2、泛素和线粒体质量控制有望成为热点和未来的研究方向。
