Don Elena, Zakharova Svetlana, Yaroshenko Sabina, Petrova Anastasia, Tarasov Sergey
R&D Department, OOO «NPF «Materia Medica Holding», Moscow, Russian Federation.
Laboratory of Physiologically Active Substances, Federal State Budgetary Scientific Institute of General Pathology and Pathophysiology, Moscow, Russian Federation.
Dose Response. 2024 Sep 25;22(3):15593258241284704. doi: 10.1177/15593258241284704. eCollection 2024 Jul-Sep.
Recently, there has been a radical change in understanding of the nature of drugs based on highly diluted solutions. It has been established that their activity does not depend on the content of the original substance in dilutions, but is a consequence of the technological processing (TP) of dilutions with vibration, which accompanies each dilution during the preparation of solutions and, among others, leads to the formation of nanoparticles with certain properties. Repeated vibration treatment leads to the appearance of modifying activity that is absent in the original substance, and these effects of TP solutions can be exerted without direct contact with their targets, which clearly indicates the physical nature of the TP solution's activity. In the framework of this article, a statistically significant effect of TP antibodies to the insulin receptor on glucose consumption by CHO cells both with and without contact exposure, as compared with control ( < 0.05) was shown in the vast majority of the experiments. The obtained results shed light on a possible source of activity of drugs based on TP antibodies, which should be associated with the applied vibration effect and can manifest itself both with contact exposure and without it.
最近，基于高度稀释溶液对药物性质的理解发生了根本性变化。已经确定，它们的活性不取决于稀释液中原始物质的含量，而是溶液制备过程中每次稀释时伴随振动的技术处理（TP）的结果，这尤其会导致形成具有特定性质的纳米颗粒。重复的振动处理会导致出现原始物质中不存在的修饰活性，并且TP溶液的这些效应可以在不直接接触其靶标的情况下发挥作用，这清楚地表明了TP溶液活性的物理性质。在本文的框架内，与对照相比（<0.05），在绝大多数实验中都显示了TP胰岛素受体抗体对CHO细胞葡萄糖消耗的统计学显著影响，无论是否有接触暴露。所得结果揭示了基于TP抗体的药物活性的可能来源，这应该与所施加的振动效应相关，并且在有接触暴露和无接触暴露的情况下都可能表现出来。
