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光感受器膜上的多巴胺受体与一种对百日咳毒素和霍乱毒素均敏感的GTP结合蛋白偶联。

Dopamine receptors on photoreceptor membranes couple to a GTP-binding protein which is sensitive to both pertussis and cholera toxin.

作者信息

Brann M R, Jelsema C L

出版信息

Biochem Biophys Res Commun. 1985 Nov 27;133(1):222-7. doi: 10.1016/0006-291x(85)91864-9.

DOI:10.1016/0006-291x(85)91864-9
PMID:3935112
Abstract

Dopamine receptors with a pharmacological profile similar to D2 receptors are coenriched with rhodopsin in preparations of bovine retinal membranes. A high density of these receptors are present on photoreceptor membranes. The affinity of the agonist apomorphine for these receptors is decreased by the guanine nucleotides GTP and GppNHp. Treatment of photoreceptor membranes with pertussis or cholera toxin also decreased the affinity of apomorphine and eliminated the effect of GTP.

摘要

在牛视网膜膜制剂中，药理学特性与D2受体相似的多巴胺受体与视紫红质共同富集。这些受体在光感受器膜上具有高密度分布。鸟嘌呤核苷酸GTP和GppNHp会降低激动剂阿扑吗啡对这些受体的亲和力。用百日咳毒素或霍乱毒素处理光感受器膜也会降低阿扑吗啡的亲和力，并消除GTP的作用。

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